Respiratory Research

Table 2 Associations of the 9 bacterial genera and Shannon diversity with tPCs both across all samples and within stable samples in generalized linear mixed models. FDR P-values are indicated in the table. Significant associations are highlighted in asterisks. Only significant variables were included in the final model unless otherwise stated

From: Airway host-microbiome interactions in chronic obstructive pulmonary disease

	Microbiome	Transcriptome
	Microbiome	tPC1	tPC2	tPC3	tPC4	tPC5	tPC6	tPC7	tPC8	tPC9
All	Veillonella	0.57	0.05*	0.91	0.39	0.32	0.53	0.71	0.82	0.70
	Prevotella	0.34	0.42	0.04*	0.25	0.93	0.92	0.59	0.59	0.14
	Haemophilus	0.01*	1E-4*	3E-3*	0.97	0.68	0.41	0.01*	0.33	0.02*
	Streptococcus	0.19	0.17	0.29	0.67	0.59	0.87	0.03*	0.36	0.36
	Moraxella	0.03*	0.45	0.88	5E-4*	0.09	0.30	0.01*	0.02*	0.02*
	Megasphaera	2E-4*	0.95	0.15	0.03*	0.28	0.78	0.91	0.84	0.79
	Neisseria	5E-3*	0.92	0.26	0.29	0.21	0.05*	0.19	0.18	0.23
	S24–7	0.72	0.73	0.38	0.52	0.94	0.84	0.80	0.57	0.46
	Selenomonas	0.29	0.97	0.13	0.24	0.09	0.04*	0.33	0.21	0.48
	Shannon	0.01*	0.10	0.02*	0.91	0.51	0.03*	0.04*	0.06	0.92
Stable	Veillonella	0.27	0.06	0.05	0.25	0.26	0.95	0.08	0.83	0.53
	Prevotella	0.37	0.36	0.27	0.51	0.56	0.67	0.27	0.90	0.27
	Haemophilus	0.10	0.01*	0.04*	0.36	0.76	0.62	0.16	0.31	0.51
	Streptococcus	0.80	0.64	0.73	0.28	0.56	3E-3*	0.08^a	0.86	0.51
	Moraxella	0.40	0.59	0.81	0.46	0.57	0.35	0.75	0.13	0.24
	Megasphaera	0.58	0.43	0.02*	0.50	0.39	0.07^a	0.45	0.67	0.78
	Neisseria	0.73	0.49	0.95	0.44	0.09^a	0.60	0.50	0.83	0.60
	S24–7	0.39	0.73	0.52	0.82	0.42	0.90	0.03*	0.72	2E-3*
	Selenomonas	0.02*	0.59	0.50	0.58	0.90	0.92	0.57	0.88	0.56
	Shannon	0.06	0.10	0.08	0.33	0.26	0.37	0.92	0.07	0.26

^aVariables not statistically significant but present in the model

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