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Table 2 Associations of the 9 bacterial genera and Shannon diversity with tPCs both across all samples and within stable samples in generalized linear mixed models. FDR P-values are indicated in the table. Significant associations are highlighted in asterisks. Only significant variables were included in the final model unless otherwise stated

From: Airway host-microbiome interactions in chronic obstructive pulmonary disease

  Microbiome Transcriptome
tPC1 tPC2 tPC3 tPC4 tPC5 tPC6 tPC7 tPC8 tPC9
All Veillonella 0.57 0.05* 0.91 0.39 0.32 0.53 0.71 0.82 0.70
Prevotella 0.34 0.42 0.04* 0.25 0.93 0.92 0.59 0.59 0.14
Haemophilus 0.01* 1E-4* 3E-3* 0.97 0.68 0.41 0.01* 0.33 0.02*
Streptococcus 0.19 0.17 0.29 0.67 0.59 0.87 0.03* 0.36 0.36
Moraxella 0.03* 0.45 0.88 5E-4* 0.09 0.30 0.01* 0.02* 0.02*
Megasphaera 2E-4* 0.95 0.15 0.03* 0.28 0.78 0.91 0.84 0.79
Neisseria 5E-3* 0.92 0.26 0.29 0.21 0.05* 0.19 0.18 0.23
S24–7 0.72 0.73 0.38 0.52 0.94 0.84 0.80 0.57 0.46
Selenomonas 0.29 0.97 0.13 0.24 0.09 0.04* 0.33 0.21 0.48
Shannon 0.01* 0.10 0.02* 0.91 0.51 0.03* 0.04* 0.06 0.92
Stable Veillonella 0.27 0.06 0.05 0.25 0.26 0.95 0.08 0.83 0.53
Prevotella 0.37 0.36 0.27 0.51 0.56 0.67 0.27 0.90 0.27
Haemophilus 0.10 0.01* 0.04* 0.36 0.76 0.62 0.16 0.31 0.51
Streptococcus 0.80 0.64 0.73 0.28 0.56 3E-3* 0.08a 0.86 0.51
Moraxella 0.40 0.59 0.81 0.46 0.57 0.35 0.75 0.13 0.24
Megasphaera 0.58 0.43 0.02* 0.50 0.39 0.07a 0.45 0.67 0.78
Neisseria 0.73 0.49 0.95 0.44 0.09a 0.60 0.50 0.83 0.60
S24–7 0.39 0.73 0.52 0.82 0.42 0.90 0.03* 0.72 2E-3*
Selenomonas 0.02* 0.59 0.50 0.58 0.90 0.92 0.57 0.88 0.56
Shannon 0.06 0.10 0.08 0.33 0.26 0.37 0.92 0.07 0.26
  1. aVariables not statistically significant but present in the model