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Table 1 Subject Characteristics

From: Chronic obstructive pulmonary disease upper airway microbiota alpha diversity is associated with exacerbation phenotype: a case-control observational study

 

Infrequent Exacerbator

Frequent Exacerbator

p value*

N

11

11

 

Sex, Male (%)

11 (100)

11 (100)

 

Age, mean (sd)

68.36 (5.45)

70.82 (7.12)

0.39

Race, white (%)

11 (100)

10 (90.9)

1.00

BMI, mean (sd)

29.25 (6.01)

26.09 (6.85)

0.26

Hypertension, Yes (%)

6 (54.5)

6 (54.5)

1.00

Diabetes, Yes (%)

2 (18.2)

3 (27.3)

1.00

COPD Severity (%)

 Moderate

5 (45.5)

3 (27.3)

 

 Severe

4 (36.4)

3 (27.3)

 

 Very Severe

2 (18.2)

5 (45.5)

 

FEV1% predicted

46.82 (13.93)

35.5 (15.18)

0.088

COPD exacerbations in the last 12 months, mean (sd)

0 (0)

2.91 (1.04)

< 0.001

COPD hospitalizations in the last 12 months, mean (sd)

0 (0)

0.55 (0.69)

0.035

Inhaled corticosteroid use, Yes (%)

6 (54.5)

7 (63.6)

1.00

Pack-years of smoking, mean (sd)

61.18 (31.94)

69.55 (48.57)

0.66

Current tobacco use, Yes (%)

5 (45.5)

3 (27.3)

0.66

Current alcohol use, Yes (%)

7 (63.6)

9 (81.8)

0.64

Brush teeth ≥ once daily (%)

9 (81.8)

10 (90.9)

1.00

History of periodontal disease, Yes (%)

3 (27.3)

2 (18.2)

1.00

SGRQ Score, mean (sd)

49.72 (7.92)

48.27 (16.20)

0.792

  1. BMI, body mass index; COPD, chronic obstructive pulmonary disease; FEV1% predicted, forced expiratory volume in 1 s, percent of predicted value; sd, standard deviation; SGRQ, St. George’s Respiratory Questionnaire
  2. *A Fisher-Pitman permutation test was conducted for all continuous variables and a Fishers exact test for all categorical variables