SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model

Respiratory Research

Table 3 Discordant Changes in Angiogenesis Profiler Array

Gene Identification		Fold-Change vs. Normoxia
Symbol	Gene Name	CH-PH	P-value	SU/CH-PH	P-value
Transcripts Modified by CH-PH, but not SU/CH-PH
Akt1	Thymoma viral proto-oncogene 1	2.22	0.007106	1.48	0.061133
Cdh5	Cadherin 5	3.65	0.000691	2.08	0.080106
Efnb2	Ephrin B2	2.29	0.042922	1.33	0.568661
Ephb4	Eph receptor B4	2.46	0.001461	1.94	0.007851
Fgfr3	Fibroblast growth factor receptor 3	2.01	0.047805	1.93	0.172211
Flt1	FMS-like tyrosine kinase 1	2.49	0.024092	1.51	0.033466
Hif1a	Hypoxia inducible factor 1, alpha subunit	2.42	0.012128	1.43	0.282336
Nrp1	Neuropilin 1	2.96	0.024777	1.80	0.166344
Smad5	MAD homolog 5 (Drosophila)	2.50	0.041301	1.43	0.224967
Tgfb3	Transforming growth factor, beta 3	2.35	0.046875	1.38	0.339163
Tnfsf12	Tumor necrosis factor (ligand) superfamily 12	2.31	0.014032	1.18	0.601718
Vegfa	Vascular endothelial growth factor A	2.30	0.048161	1.69	0.05109
Transcripts Modified by SU/CH-PH, but not CH-PH alone
Angpt1	Angiopoietin 1	1.04	0.891137	−2.34	0.012238
Cxcl5	Chemokine (C-X-C motif) ligand 5	3.56	0.05293	2.43	0.031585
Il1b	Interleukin 1 beta	2.23	0.200162	2.29	0.034526
Il6	Interleukin 6	2.46	0.066759	2.60	0.022390
Mmp19	Matrix metallopeptidase 19	2.06	0.131679	2.87	0.002957
Tgfbr1	Transforming growth factor, beta receptor 1	2.71	0.082286	2.15	0.042879
Tnf	Tumor necrosis factor	3.15	0.070061	2.68	0.002550

P-values are for Student’s t-test comparing the experimental (n = 3/group) to control (Normoxia; n = 4) groups. CH-PH = chronic hypoxic pulmonary hypertension; SU/CH-PH = SU5416 + chronic hypoxic pulmonary hypertension

ISSN: 1465-993X