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Table 2 Concordant Changes in Angiogenesis Profiler Array

From: SU5416 does not attenuate early RV angiogenesis in the murine chronic hypoxia PH model

Gene Identification

Fold-Change vs. Normoxia

Symbol

Gene Name

CH-PH

P-value

SU/CH-PH

P-value

Angpt2

Angiopoietin 2

2.75

0.003788

2.61

0.005498

Ccl2

Chemokine (C-C) motif ligand 2

7.76

0.019500

8.39

0.024364

Col18a1

Collagen, type XVIII, alpha 1

3.70

0.000009

3.60

0.010498

Cxcl2

Chemokine (C-X-C) motif ligand 2

2.70

0.008983

3.24

0.005886

Eng

Endoglin

3.08

0.002967

2.02

0.034330

Fn1

Fibronectin 1

4.05

0.004777

3.19

0.031768

Hgf

Hepatocyte growth factor

2.85

0.000241

2.27

0.001051

Kdr

Kinase insert domain protein receptor

3.15

0.031063

2.08

0.049350

Mmp14

Matrix metallopeptidase 14

3.58

0.005553

2.77

0.002366

Nrp2

Neuropilin 2

3.50

0.004670

3.33

0.004227

Pecam1

Platelet/endothelial cell adhesion molecule-1

3.65

0.009939

2.33

0.049902

Plau

Plasminogen activator, urokinase

4.27

0.013232

3.07

0.014172

Ptk2

PTK2 protein tyrosine kinase 2

2.76

0.033783

2.03

0.012938

Tgfb1

Transforming growth factor, beta 1

2.77

0.011717

2.51

0.010149

  1. P-values are for Student’s t-test comparing the experimental (n = 3/group) to control (Normoxia; n = 4) groups. CH-PH = chronic hypoxic pulmonary hypertension; SU/CH-PH = SU5416 + chronic hypoxic pulmonary hypertension