Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough

Respiratory Research

Table 3 Clinical characteristics of patients with different phenotypes of cough hypersensitivity

	AITC (+) Capsaicin (+)	AITC (+) Capsaicin (−)	AITC (−) Capsaicin (+)	AITC (−) Capsaicin (−)	P
Female^a	19 (76.0)	25 (56.8)	20 (71.4)	56 (40.8)	0.001
Age (years)^b	42.0 ± 11.5	44.0 ± 13.5	44.5 ± 13.1	41.3 ± 13.5	0.909
Cough duration (months)^c	12.0 (2.0–480.0)	14.5 (2.0–360.0)	21.0 (2.0–480.0)	18.0 (2.0–480.0)	0.664
Daytime cough score^b	2.5 ± 1.0	2.6 ± 0.7	2.9 ± 0.9	2.7 ± 0.8	0.371
Laryngeal paresthesia^a	19 (76.0)	38 (86.4)	23 (82.1)	107 (78.1)	0.627
Cough triggers^a
Odours	19 (76.0)	27 (61.4)	23 (82.1)	92 (67.1)	0.237
Cold air	12 (48.0)	17 (38.6)	16 (57.1)	65 (47.4)	0.491
Dusty environment	11 (44.0)	19 (43.2)	16 (57.1)	58 (42.3)	0.551
Talking	10 (40.0)	23 (52.3)	12 (42.9)	45 (32.8)	0.131

^a Data are expressed as n (%); ^b Data are expressed as mean ± SD; ^c Data were expressed as median (range);
+: Increased cough sensitivity to AITC or capsaicin; −: Normal cough sensitivity to AITC or capsaicin

ISSN: 1465-993X