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Table 3 Lung function in each study group

From: Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma

  BPD
n = 26
Preterm
n = 23
Asthma
n = 23
Healthy controls
n = 24
FEV1 z-scoresa −0.94***
(− 1.57; −0.08)
0.28
(−0.27; 1.18)
0.14
(−0.52; 0.77)
0.78
(−0.03; 1.26)
FEV1% pred.a 88.9***
(81.4; 99.1)
103.3
(96.9; 113.3)
101.7
(94.1; 109.0)
108.9
(99.7; 114.1)
FVC z-scoresa −0.32*
(− 1.24; 0.14)
− 0.26
(− 0.64; 0.60)
0.13
(− 0.48; 0.85)
0.37
(− 0.18; 0.85)
FVC % pred.a 96*
(85.6; 101.7)
96.9
(92.2; 107.5)
101.6
(94.5; 110.4)
104.6
(97.9; 109.8)
FEV1/FVCb 0.82***
(0.79; 0.85)
0.91
(0.87; 0.94)
0.86
(0.83; 0.89)
0.90
(0.87; 0.93)
FEV1/FVC
z-scores a
−0.67***
(−1.86; 0.18)
0.82
(0.13; 1.33)
−0.20*
(− 0.43; 0.33)
0.42
(− 0.26; 0.89)
Reversibility % 6.9
(3.3; 10.9)
3.7
(1.4; 7.6)
5.9
(3.7; 8.3)
4.3
(1.9; 6.2)
Methacholine challenge pos. 19 (73) 13 (56) 23 (100) 0
TLC % pred.a 95*
(87.5; 101.5)
97
(92; 114)
99
(95; 106)
104
(95.5; 108)
RV % pred.a 88
(60.5; 99.5)
79
(65; 132)
72.5
(52; 96)
84.5
(68.5; 105.5)
VC % pred.a 96.5**
(88; 106)
103
(96; 110)
106
(99; 113)
107
(100.5; 115.5)
RV/TLC 20
(17; 24.5)
20.5
(17.5; 22.5)
18.5
(14; 23)
19
(17; 22.5)
DLCO adj % pred.a 67***
(64; 73)
73***
(65; 83)
81.5
(75; 91)
86.5
(80; 96)
LCIa 6.97***
(6.84; 7.72)
6.73
(6.29; 7.12)
6.75
(6.37; 7.08)
6.50
(6.31; 6.72)
R5–20
(kPa/L/sec)b
0.014
(−0.002; 0.030)
0.021
(0.003; 0.039)
0.015
(−0.003; 0.033)
0.007
(− 0.010; 0.024)
AX0.5
(kPa/L)b
0.156
(0.120; 0.192)
0.163
(0.123; 0.202)
0.140
(0.099; 0.181)
0.125
(0.086; 0.164)
  1. BPD-, Preterm- and asthma- groups were compared to healthy controls. Data are presented as median (IQR) numbers (%). All dynamic spirometry measures (FEV1, FVC, FEV1/FVC) and the impulse oscillometry data (R5–20, AX) are post bronchodilator (four doses of salbutamol 0.1 mg/dose) measures
  2. aAnalysis with quantile regression on median
  3. bAnalysis with quantile regression on median adjusting for age, sex and height
  4. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001, comparing BPD-, preterm- and asthma-groups to healthy controls
  5. Abbreviations: BPD bronchopulmonary dysplasia, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, TLC total lung capacity, RV residual volume, VC vital capacity, DLCO adj diffusing capacity of the lung for Carbon monoxide adjusted for blood haemoglobin, LCI lung clearance index, R5–20 resistance at 5–20 Hz, AX0.5 square root of the area of reactance, IQR Inter quartile range