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Table 3 Risk ratio of early life risk factors for developing pulmonary function test trajectories

From: Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort study

Variables

Male participants

Female participants

Low FVC-trajectory (n = 661)

Low FEV1-trajectory (n = 501)

Low FEV1/FVC trajectory (n = 480)a

Low and medium FEF25–75% trajectories (n = 480)

Low FVC-trajectory (n = 654)

Low FEV1-trajectory (n = 468)a

Low FEV1/FVC trajectory (n = 733)

Low and medium FEF25–75% trajectories (n = 542)

Risk Ratio (95% CI)

Risk Ratio (95% CI)

Risk Ratio (95% CI)

Odds Ratios (95%CI)

Risk Ratio (95% CI)

Risk Ratio (95% CI)

Risk Ratio (95% CI)

Odds Ratios (95%CI)

Birth weight (change in risks/odds per kilogram)

0.87 (0.78, 0.96)

0.87 (0.78, 0.97)

0.71 (0.52, 0.98)

Low vs. high: 0.27 (0.13, 0.55) medium vs. high 0.36 (0.18, 0.75)

0.78 (0.70, 0.86)

0.69 (0.57, 0.83)

Low vs. high: 0.48 (0.29, 0.8) medium vs. high 0.73 (0.47, 1.14)

Duration of breastfeeding (change in risks/odds per week)

0.995 (0.991, 0.999)

  

 

Eczema in the first year of life

1.35 (1.12, 1.63)

1.39 (1.11, 1.75)

1.66 ¥ (1.001–2.77)

Low vs. high: 3.55 (1.36, 9.26) medium vs. high 1.6 (0.63, 4.03)

Skin prick test positivity at age 4

1.64 (1.14–2.36)

 

1.32 (1.07, 1.63)

 

Asthma at four 4 of age

1.15 (1.01, 1.32)

1.68 (1.17, 2.43)

  

 
  1. aLower number of participants, since Skin prick test at 4 years was involved
  2. ¥ No effect of eczema in the first year of life, when birthweight was in the model. However, eczema in the first year of life gained statistical significance, when height at 4 years of age was controlled for instead of birth weight