Fig. 2

Increased RAGE signal on SPECT/CT in 4-week smoke-exposed rabbits. a Transverse SPECT/CT slices from the mid lung fields for 4-week and 16-week smoke-exposed and room air control rabbits. The tracer uptake is highest in the lungs of 4-week smoke exposed rabbits. The color table scaling reference bar for the SPECT images shows the upper and lower threshold levels selected to optimally display lung uptake of radiotracer. The (b) %ID for the right and left lung quantifications, data provided as mean ± SD, n = 4–5 per group. c Gamma well counting significantly correlates with the %ID as calculated on imaging analysis across all imaging situations