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Table 1 Arterial blood gas analyses

From: Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia

  Control LPS
NS norNOHA
(40mg/kg)
NS norNOHA
(20mg/kg)
norNOHA
(40mg/kg)
PaO2
(mmHg)
267±38 200±38* 178±13* 204±44* 234±25§
PaCO2
(mmHg)
30.9±5.1 30.9±3.5 34.0±5.0 36.7±8.4 30.7±4.8
pHa
(mmHg)
7.31±0.10 7.37±0.05 7.13±0.07*‡ 7.07±0.08*‡ 7.11±0.04*‡
BE
(mmol/l)
-9.0±5.1 -6.4±2.0* -17.5±1.6*‡ -18.4±4.6*‡ -19.7±2.5*‡
Hb
(g/dl)
13.0±1.0 13.0±1.1 11.8±1.1 11.7±1.4 11.8±1.3
  1. Mice were challenged with saline (control) or endotoxin (LPS). After 21 h, animals received treatment with normal saline (NS) or the arginase inhibitor Nω-hydroxy nor-Arginine (norNOHA). Blood gas analyses were performed during occlusion of the left mainstem bronchus. N = 7 per group
  2. PaO2 arterial oxygen tension, PaCO2 arterial carbon dioxide tension, pHa arterial pH, BE base excess, Hb hemoglobin, mmHg millimeters of mercury, mmol / l milimoles per liter, g/dl gram per deciliter
  3. Data are presented as mean ± SD. * P < 0.05 vs. control NS, § P < 0.05 vs. LPS NS, ‡ P < 0.05 vs. control norNOHA