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Table 1 Arterial blood gas analyses

From: Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia

 

Control

LPS

NS

norNOHA

(40mg/kg)

NS

norNOHA

(20mg/kg)

norNOHA

(40mg/kg)

PaO2

(mmHg)

267±38

200±38*

178±13*

204±44*

234±25§

PaCO2

(mmHg)

30.9±5.1

30.9±3.5

34.0±5.0

36.7±8.4

30.7±4.8

pHa

(mmHg)

7.31±0.10

7.37±0.05

7.13±0.07*‡

7.07±0.08*‡

7.11±0.04*‡

BE

(mmol/l)

-9.0±5.1

-6.4±2.0*

-17.5±1.6*‡

-18.4±4.6*‡

-19.7±2.5*‡

Hb

(g/dl)

13.0±1.0

13.0±1.1

11.8±1.1

11.7±1.4

11.8±1.3

  1. Mice were challenged with saline (control) or endotoxin (LPS). After 21 h, animals received treatment with normal saline (NS) or the arginase inhibitor Nω-hydroxy nor-Arginine (norNOHA). Blood gas analyses were performed during occlusion of the left mainstem bronchus. N = 7 per group
  2. PaO2 arterial oxygen tension, PaCO2 arterial carbon dioxide tension, pHa arterial pH, BE base excess, Hb hemoglobin, mmHg millimeters of mercury, mmol / l milimoles per liter, g/dl gram per deciliter
  3. Data are presented as mean ± SD. * P < 0.05 vs. control NS, § P < 0.05 vs. LPS NS, ‡ P < 0.05 vs. control norNOHA
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Respiratory Research

ISSN: 1465-993X

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