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Fig. 10 | Respiratory Research

Fig. 10

From: Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase

Fig. 10

Summary of our findings and a proposed mechanism by which BK sensitize the cough reflex centrally. Bradykinin acts on B2 receptors (B2R) on second order neurons to stimulate the release of COX and 12-LOX metabolites which in turn activate TRPV1 and TRPA1 channels on the second order neurons resulting in an enhanced cough response

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Respiratory Research

ISSN: 1465-993X

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