Table 2 (A) Time to all-cause death (and breakdown by adjudicated cause) and time to first (B) moderate/severe COPD exacerbation, (C) severe COPD exacerbation and (D) cardiovascular (CV) composite event by baseline platelet count
Event | Platelet Count Quintile Group 1: < 173 (N = 363) | Platelet Count Quintile Group 2: > = 173 to < 205 (N = 356) | Platelet Count Quintile Group 3: > = 205 to < 234 (N = 354) | Platelet Count Quintile Group 4: > = 234 to < 272 (N = 364) | Platelet Count Quintile Group 5: > = 272 (N = 359) |
|---|---|---|---|---|---|
(A) | |||||
 All-cause Mortality | 30 (8.3%) | 17 (4.8%) | 16 (4.3%) | 13 (3.7%) | 30 (8%) |
 Hazard Ratio (95% CI), vs. Quintile group 3 | 1.73 (0.93, 3.23) | 0.97 (0.48, 1.96) | -REF- | 0.77 (0.37, 1.61) | 1.66 (0.89, 3.10) |
Cause Specific Death | |||||
 Respiratory | 6 (20%) | 2 (12%) | 1 (6%) | 1 (8%) | 2 (7%) |
 Cardiovascular | 6 (20%) | 5 (29%) | 6 (38%) | 6 (46%) | 9 (30%) |
 Cancer | 11 (37%) | 5 (29%) | 4 (25%) | 4 (31%) | 7 (23%) |
 Other | 5 (17%) | 2 (12%) | 1 (6%) | 0 (0%) | 3 (10%) |
 Unknown | 2 (7%) | 3 (18%) | 4 (25%) | 2 (15%) | 9 (30%) |
(B) | |||||
 Moderate/Severe COPD Exacerbation | 129 (36%) | 115 (32%) | 132 (37%) | 128 (35%) | 147 (41%) |
 Hazard Ratio (95% CI), vs. Quintile group 3 | 0.91 (0.71, 1.17) | 0.82 (0.63, 1.06) | -REF- | 0.87 (0.68, 1.12) | 1.00 (0.79, 1.28) |
(C) | |||||
 Severe COPD Exacerbation | 35 (10%) | 25 (7%) | 27 (8%) | 33 (9%) | 39 (11%) |
 Hazard Ratio (95% CI), vs. Quintile group 3 | 1.16 (0.69, 1.95) | 1.00 (0.57, 1.74) | -REF- | 1.20 (0.71, 2.02) | 1.33 (0.80, 2.21) |
(D) | |||||
 CV Composite Event | 23 (6%) | 15 (4%) | 13 (4%) | 15 (4%) | 20 (6%) |
 Hazard Ratio (95% CI), vs. Quintile group 3 | 1.41 (0.70, 2.85) | 1.11 (0.52, 2.37) | -REF- | 1.14 (0.53, 2.45) | 1.71 (0.83, 3.49) |