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Table 2 Assessment of Ig stability upon nebulization by size exclusion chromatography. Ig formulations were nebulized or left untreated and then analyzed by size exclusion chromatography. Percentage of fragments, monomers, dimers, polymers and high molecular species (HMS) are reported

From: Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates

Formulation Condition Polymers & HMS (%) Monomers and Dimers (%) Fragments (%)
IgG 10% non-nebulized < 1 > 98 < 1
nebulized < 1 > 98 < 1
IgG 5% non-nebulized < 1 > 98 1
nebulized < 1 > 98 < 1
IgA 5% non-nebulized 23 74 3
nebulized 23 74 3
IgAM 5% non-nebulized 62 34 4
nebulized 60 35 5