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Table 1 Aerosol characterization upon nebulization of distinct Ig formulations. GSD: Geometric Standard Deviation (Width of deviation curve of droplet sizes)

From: Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates

Formulation Concentration (mg/ml) Viscosity (20 °C) (mPa*s) Total Output Rate (mg/min) Mass Median Diameter (mm) GSD Respirable Fraction <  5 μm (%) Nebulization time (min) (2 ml)
Saline 0.9% ~ 1.09 1072 ± 225 4.35 ± 0.25 1.76 ± 0.04 59.89 ± 4.29 n.d. (~ 1.8–2.0 min)
IgG 10% 100 3.2 ± 0.03 602 ± 88 3.74 ± 0.07 1.53 ± 0.07 76.87 ± 2.04 3 ± 0.4
IgG 5% 50 1.77 ± 0.01 812 ±132 3.98 ± 0.09 1.60 ± 0.02 69.68 ± 2.33 2.2 ± 0.4
IgA 5% 50 2.31 ± 0.01 700 ± 90 3.86 ± 0.10 1.57 ± 0.03 73.13 ± 2.97 2.6 ± 0.3
IgAM 5% 50 3.74 ± 0.02 681 ± 38 3.73 ±0.11 1.55 ± 0.03 76.46 ± 3.24 2.4 ± 0.2