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Table 3 Correlations between serum YKL-40 and clinical characteristics

From: Chitinase-like protein YKL-40 correlates with inflammatory phenotypes, anti-asthma responsiveness and future exacerbations

Clinical characteristics YKL-40 (ng/mL)
r P value
Age, yr.a 0.55 < 0.001
Smoking, pack-years 0.22 0.019
FEV1% predicteda −0.27 0.004
FEV1/FVC %a −0.34 < 0.001
ACQ −0.06 0.559
FENO, ppba −0.12 0.220
IgE, IU/mLa −0.22 0.021
Cell count in peripheral blood
 Eosinophils, 109/L −0.23 0.016
 Eosinophils, % −0.24 0.009
 Neutrophils, 109/La 0.09 0.365
 Neutrophils, %a 0.19 0.046
 Monocytes, 109/La 0.23 0.016
 Monocytes, %a 0.26 0.005
Systemic cytokines
 IL-6, pg/mLa 0.32 0.003
 CCL22, pg/mLa 0.21 0.066
Cell count in induced sputum
 Eosinophils, 106/mL 0.05 0.710
 Eosinophils, % 0.02 0.859
 Neutrophils, 106/mL −0.01 0.913
 Neutrophils, %a 0.08 0.567
 Macrophages,106/mL −0.18 0.175
 Macrophages, %a −0.07 0.622
Cytokines in sputum
 IL-1β, pg/mL 0.24 0.037
 IL-5, pg/mL −0.01 0.971
 TNF-α, pg/mLa 0.10 0.376
 IL-8, pg/mL 0.20 0.077
  1. ACQ asthma control questionnaire, CCL chemokine (C-C motif) ligand, FENO fractional exhaled nitric oxide, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, IL interleukin, TNF tumor necrosis factor
  2. aPearson’s coefficient tests