Fig. 5
From: Role of TRPC1 channels in pressure-mediated activation of airway remodeling
Analysis of TRPC1 expression and airway remodeling for the control, OVA,. OVA+TRPC1 siRNA, OVA+NC siRNA and OVA+budesonide groups. a Pulmonary sections. Were subjected to immunohistochemistry experiments, HE and Masson staining. All. photomicrographs were captured at × 400. b We observed different airway wall thicknesses,. smooth muscle thicknesses and collagen deposition area. c Quantification of TRPC1 protein. Was performed by western blot. β-actin served as the internal control. d IOD/area of TRPC1. protein and expression of TRPC1 mRNA are shown above. The results above mean that. TRPC1 could active and accelerate the airway remodeling. All data were collected after eight. Weeks sand shown as the means ± SD (n = 5). OVA: ovalbumin. *P < 0.05