Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD

Table 5 Post-hoc analysis of differences between groups with various degrees of emphysema as described in Table 4

		ESI	FEV₁%	FVC%	FEV₁/FVC%	TLC%	RV%	FRC%	DLco%
VIDA	p NE/ME	<.01	<.01	<.01	<.01	.28	<.01	<.01	<.01
	p NE/SE	<.01	<.01	<.01	<.01	<.01	<.01	<.01	<.01
	p ME/SE	<.01	<.01	.52	<.01	<.01	<.01	<.01	<.01
Imbio LDA	p NE/ME	<.01	.16	.96	<.01	<.01	<.01	<.01	.21
	p NE/SE	<.01	<.01	.56	<.01	<.01	<.01	<.01	<.01
	p ME/SE	<.01	<.01	.54	<.01	.42	.23	.02	<.01
CALIPER	p G1/G2	<.01	<.01	.52	<.01	<.01	<.01	<.01	<.01
	p G2/G3	<.01	<.01	<.01	<.01	.28	<.01	<.01	<.01
	p G1/G3	<.01	<.01	<.01	<.01	<.01	<.01	<.01	<.01

Groups are defined according the classification performed by VIDA and Imbio LDA (NE, ME, SE) and by CALIPER (G1, G2, G3). Differences were analyzed by Games-Howell post-hoc test and p values are displayed (significant p values are in bold). Legend: DLco % percent predicted diffusing lung capacity for carbon monoxide, FEV₁% percent predicted forced expiratory volume in 1 s, FRC% percent predicted functional residual capacity, FVC% percent predicted forced vital capacity, %LAA_-950insp percentage of lung attenuation area with values <−950 Hounsfield Units at inspiratory CT scan, ME (moderate emphysema, 6 ≤ %LAA_-950insp < 14 if VIDA or 6 ≤ %pLDA < 14 if Imbio LDA), NE (no emphysema, %LAA_-950insp < 6 if VIDA or %pLDA < 6 if Imbio LDA), RV% percent predicted residual volume, SE (severe emphysema, %LAA_-950insp ≥ 14 if VIDA or %LAA_-950insp ≥ 14 if Imbio LDA), TLC% percent predicted total lung capacity

ISSN: 1465-993X