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Table 4 Relationship among ESI values and functional data across the groups of patients with various degrees of emphysema

From: Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD

Emphysema severity

N

ESI score

FEV1%

FVC %

FEV1/FVC %

TLC %

RV %

FRC %

DLco %

VIDA

 NE

57

1.1 (1.5)

76.1 (23.6)

93.5 (22.8)

63.1 (8.0)

100.1 (11.8)

115.0 (30.5)

109.3 (18.2)

79.7 (22.9)

 ME

58

3.1 (2.6)

63.6 (23.9)

91.4 (21.0)

54.1 (10.2)

106.9 (18.8)

134.1 (51.7)

125.3 (31.0)

75.6 (21.6)

 SE

79

6.8 (2.5)

49.9 (23.7)

91.2 (27.8)

42.4 (10.8)

115.2 (15.1)

157.6 (48.2)

147.9 (33.7)

55.9 (19.8)

ANOVA / Welch’s test p

 

<.001

<.001

.002

<.001

<.001

<.001

<.001

<.001

Imbio LDA

 NE

86

1.5 (1.8)

72.6 (22.9)

92.9 (20.9)

60.5 (9.2)

101.1 (15.6)

118.2 (42.0)

111.5 (23.7)

78.9 (23.2)

 ME

46

4.6 (2.7)

63.8 (27.5)

94.1 (25.2)

52.1 (10.1)

111.9 (15.0)

145.6 (47.4)

135.4 (30.5)

72.6 (18.1)

 SE

62

7.7 (3.3)

44 (18.8)

88.6 (28.2)

39.6 (9.5)

115.7 (15.5)

160.7 (46.2)

152.1 (32.5)

51.9 (18.9)

ANOVA / Welch’s test p

 

<.001

<.001

.442

<.001

<.001

<.001

<.001

<.001

CALIPER

 G1

95

1.7 (2.1)

71.9 (23.7)

92.8 (21.9)

59.8 (9.6)

101.2 (14.6)

118.7 (39.4)

113.2 (24.3)

78.4 (23.2)

 G2

65

5.4 (2.8)

59.7 (24.9)

97.1 (26.5)

48.8 (11.0)

113.4 (16.5)

145.9 (47.6)

137.9 (30.7)

65.6 (19.0)

 G3

34

8.0 (1.7)

36.8 (14.3)

79.5 (23.2)

36.5 (8.0)

118.2 (13.6)

177.3 (44.0)

163.4 (29.9)

48.1 (18.5)

ANOVA / Welch’s test p

 

<.001

<.001

.002

<.001

<.001

<.001

<.001

<.001

  1. Differences among groups were assessed by analysis of variance and Welch’s tests, expressed in italics and in bold if significant. Values are expressed as mean (SD). DLco % percent predicted diffusing lung capacity for carbon monoxide, FEV1% percent predicted forced expiratory volume in 1 s, FRC% percent predicted functional residual capacity, FVC% percent predicted forced vital capacity, %LAA-950insp percentage of lung attenuation area with values <−950 Hounsfield Units at inspiratory CT scan, ME (moderate emphysema, 6 ≤ %LAA-950insp < 14 if VIDA or 6 ≤ %pLDA < 14 if Imbio LDA), NE (no emphysema, %LAA-950insp < 6 if VIDA or %pLDA < 6 if Imbio LDA), RV% percent predicted residual volume, SE (severe emphysema, %LAA-950insp ≥ 14 if VIDA or %LAA-950insp ≥ 14 if Imbio LDA), TLC% percent predicted total lung capacity