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Table 2 Clinical Diagnosis Definitions

From: A prospective multicentre study testing the diagnostic accuracy of an automated cough sound centred analytic system for the identification of common respiratory disorders in children

Disease Required features to reach a clinical diagnosis
Upper respiratory tract disease (URTD) • Nasal congestion, rhinorrhoea or a sore throat.
Lower respiratory tract disease (LRTD) • One or more of the following:
Wheezing or silent chest (in the setting of obstruction) at the time of recording
Any auscultatory findings, including crackles, bronchial breath sounds, or focally decreased breath sounds
Increased work of breathing unless purely associated with stridor
A productive cough > 5 days
New consolidation, infiltrate or pleural effusion on CXR
Asthma/RAD • Wheeze or silent chest at the time of recording
• Responsive to bronchodilators during this illness
• Diagnosis is Unsure if:
No bronchodilator testa administered
Pre-treated with bronchodilators with wheeze resolved at the time of recording
Bronchiolitis • Age < 24 months
• Must have both:
o A persistent cough and
o Diffuse wheeze that is non-responsive to bronchodilator (if administered) and/or diffuse crackles
Pneumonia (Focal) At least one feature from both of the following categories:
1. History of: (i) fever in prior 48 h or fever at the time of examination, (ii) cough, (iii) dyspnoea, or (iv) chest pain
2. Either focalb examination findings including crackles, bronchial breath sounds, focal decreased breath sounds; OR
A chest radiograph with new consolidation with normal auscultation findings
Croup • Typical seal-like barking cough on the cough recording.
  1. a Bronchodilator test: administration of Salbutamol MDI via spacer up to 3 times over 1 h at the following doses: 6 puffs for children < 6 yrs., 12 puffs for children > 6 yrs.
  2. b Pneumonia (Focal) implies the absence of generalised findings on auscultation reflecting generalised LRTD such as RAD and bronchiolitis