From: Effect of N-acetylcysteine on exacerbations of bronchiectasis (BENE): a randomized controlled trial
Characteristic | Group | P-value | |
---|---|---|---|
Control group (N = 80) | N-acetylcysteine group (N = 81) | ||
Gender | |||
 Female, n (%) | 52 (65.0) | 45 (55.6) | 0.144 |
Age, years | 56.56 ± 12.41 | 53.28 ± 11.90 | 0.089 |
Body mass index, kg/m2 | 22.16 ± 4.22 | 22.72 ± 3.57 | 0.362 |
Ex-smoker, n (%) | 8 (10.0) | 6 (7.4) | 0.381 |
mMRC score(≥2) | 48 (60.0) | 45 (55.6) | 0.341 |
CAT score | 19.55 ± 7.26 | 19.15 ± 7.12 | 0.723 |
24-h sputum volume, mL | 28.84 ± 40.94 | 29.74 ± 41.35 | 0.890 |
Etiology of bronchiectasis | Â | Â | 0.179 |
 Postinfectious | 38 (47.5) | 30 (37.0) |  |
 Idiopathic | 42 (52.5) | 51 (63.0) |  |
HRCT grade, n (%) | 0.194 | ||
 1 | 28 (35.0) | 27 (33.3) | |
 2 | 41 (51.2) | 34 (42.0) | |
 3 | 11 (13.8) | 20 (24.7) | |
Number of lesion lobes, n (%) | 0.822 | ||
 1 lobe | 15 (18.8) | 18 (22.2) | |
 2–3 lobes | 47 (58.8) | 44 (54.3) | |
 4–6 lobes | 18 (22.5) | 19 (23.5) | |
Cystiform bronchiectasis, n (%) | 33 (41.2) | 44 (54.3) | 0.097 |
Pseudomonas aeruginosa positive, n (%) | 20 (25.0) | 27 (33.3) | 0.245 |
Medications, n (%) | |||
 Inhaled corticosteroids and long-acting β-agonist | 45 (56.2) | 56 (69.1) | 0.091 |
 Inhaled short-acting β-agonist | 20 (25.0) | 15 (18.5) | 0.391 |
 Inhaled anticholinergics | 22 (27.5) | 24 (29.6) | 0.765 |
 Inhaled corticosteroids | 17 (21.2) | 11 (13.6) | 0.199 |
Prednisone | 2 (2.5) | 3 (3.8) | 1.000 |
Theophylline | 6 (7.5) | 4 (5.0) | 0.746 |
Pulmonary function | |||
 FVC, L | 2.42 ± 0.94 | 2.32 ± 0.74 | 0.483 |
 FEV1, L | 1.56 ± 0.81 | 1.62 ± 0.73 | 0.629 |
 Predicted FEV1, % | 63.63 ± 26.28 | 60.23 ± 27.32 | 0.451 |
 FEV1/FVC, % | 64.39 ± 14.63 | 67.44 ± 16.49 | 0.226 |
 Inspiratory capacity, L | 1.77 ± 0.70 | 1.88 ± 0.81 | 0.368 |
ESR, mm/h | 25.39 ± 19.86 | 27.53 ± 24.07 | 0.540 |
CRP, mg/dL | 16.99 ± 21.26 | 13.37 ± 17.12 | 0.246 |
Number of exacerbations in the last year | 2 (2–3) | 2 (2–3) | 0.713 |
Bronchiectasis Severity Index | 8.00 ± 4.27 | 8.43 ± 4.68 | 0.548 |