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Fig. 2 | Respiratory Research

Fig. 2

From: Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia

Fig. 2

Gene expression levels of stem cell-related markers and inflammatory markers. Total RNA from PAs was used for reverse transcription (RT), and quantitative polymerase chain reaction (qPCR) was performed. The message was normalized to β-actin using the 2-∆∆CT eq. a Silibinin did not downregulate the expression of stem cell-related and inflammatory markers in PAs after a 1-week treatment. b Silibinin significantly downregulated the expression of CXCR4, SDF-1 as well as TNFα in PAs after a 2-week treatment. c Silibinin did not downregulate the expression of stem cell-related and inflammatory markers in PAs after a 3-week treatment. d Silibinin did not downregulate the expression of stem cell-related and inflammatory markers in lung tissue after a 2-week treatment; **p < 0.01. Treatment groups consisted of eight rats each in the PAH-1w, PAH-2w, Sil-1w, and Sil-2w groups and four rats each in the PAH-3w and Sil-3w groups

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Respiratory Research

ISSN: 1465-993X

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