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Fig. 1 | Respiratory Research

Fig. 1

From: AGER expression and alternative splicing in bronchial biopsies of smokers and never smokers

Fig. 1

Smokers show lower AGER expression and increased esRAGE expression. a Patient characteristics of 37 active smokers and 40 never smokers used for all experiments in this study. BMIā€‰=ā€‰body mass index as kg/m2, Packyearsā€‰=ā€‰number of years smoking one pack of 20 cigarettes per day, FVCā€‰=ā€‰Forced vital capacity, FEV1ā€‰=ā€‰Forced expiratory volume in one second. Data is shown as meanā€‰Ā±ā€‰SEM. b AGER mRNA expression was measured in lung tissue obtained from bronchial biopsy material in smokers and never smokers without airway obstruction. Gene expression expressed as Fragments Per Kilobase Million (fpmk). c Graphical representation of the AGER exon structure and sequences spanning the exon-exon junctions (split reads). d Percentage of expression of split reads compared to total split read count per patient for all exon-exon junctions and alternative splicing sites. e Percentage of expression of split reads compared to total split read count per patient for esRAGE. All data is shown as individual measurements and meanā€‰Ā±ā€‰SEM. Significance was tested using a Mann Whitney-U test,* pā€‰ā‰¤ā€‰0.05, ** pā€‰<ā€‰0.01

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