Table 4 Genome-wide significant loci by cross-trait meta-analysis at sentinel SNPs associated with COPD and CAD (Pmeta < 5 × 10−8; single trait P < 0.01)
Sentinel SNP | CHR | N | Position | P CAD | P COPD | P META | Variant annotation | Genes within clumping region |
|---|---|---|---|---|---|---|---|---|
rs2128739 | 11 | 13 | chr11:103660567–103,718,660 | 7.05 × 10−11 | 3.69 × 10−3 | 3.17 × 10−12 | Intergenic | RP11-563P16.1 |
rs8046697 | 16 | 164 | chr16:75236763–75,516,534 | 3.24 × 10−6 | 8.1 × 10−4 | 3.80 × 10−8 | Intron | BCAR1, CFDP1, CHST6, CTRB1, CTRB2, LOC100506281, TMEM170A |
rs8108474 | 19 | 27 | chr19:46190268–46,370,381 | 7.51 × 10−6 | 5.62 × 10−5 | 1.49 × 10−8 | Intron | DMPK, DMWD, FBXO46, FOXA3, LOC388553, QPCTL, RSPH6A, SIX5, SNRPD2, SYMPK |