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Table 2 Genome-wide significant loci by cross-trait meta-analysis at sentinel SNPs associated with COPD and RHR (Pmeta < 5 × 10− 8; single trait P < 0.01)

From: Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis

Sentinel SNP

CHR

N

Position

P RHR

P COPD

P META

Variant annotation

Genes within clumping region

rs3738676

1

162

chr1:39552963–40,088,043

2.30 × 10− 10

1.51 × 10− 3

3.07 × 10− 11

3′ UTR

BMP8A, KIAA0754, MACF1, PABPC4, PPIEL, SNORA55

rs59985166

1

47

chr1:10653622–10,753,094

2.50 × 10−16

2.92 × 10− 3

4.08 × 10−18

Intron

CASZ1, PEX14

rs13409705

2

17

chr2:28820641–29,115,712

2.80 × 10− 10

6.57 × 10− 4

8.61 × 10− 12

Intron

PLB1, PPP1CB, SPDYA, TRMT61B

rs3791979

2

21

chr2:218667372–218,704,894

2.40 × 10− 9

4.15 × 10− 3

2.0 × 10− 9

3′ UTR

TNS1

rs2955083

3

119

chr3:127715196–128,067,275

6.90 × 10− 4

2.0 × 10−8

3.56 × 10− 8

Intron

EEFSEC, RUVBL1, SEC61A1

rs9859058

3

78

chr3:156353161–156,695,011

3.60 × 10−10

6.57 × 10−3

4.01 × 10− 11

Intron

LEKR1, LINC00886, PA2G4P4, TIPARP, TIPARP-AS1

rs7655625

4

140

chr4:145196359–145,974,688

2.70 × 10−5

3.02 × 10−19

1.92 × 10− 19

Intergenic

ANAPC10, HHIP, HHIP-AS1

rs7449334

5

43

chr5:90309787–90,418,617

1.0 × 10− 10

3.59 × 10− 3

1.62 × 10−11

Intron

GPR98

rs1158317

6

5

chr6:120518685–121,035,654

6.50 × 10−11

7.45 × 10−3

1.19 × 10− 11

Intergenic

C6orf170*

rs12173787

6

144

chr6:33350201–33,789,899

1.20 × 10−15

5.4 × 10−3

2.79 × 10− 15

Downstream gene

BAK1, CUTA, GGNBP1, IP6K3, ITPR3, KIFC1, LEMD2, LINC00336, MIR5004, MLN, PHF1, SYNGAP1, UQCC2, ZBTB9

rs57942103

8

11

chr8:106513461–106,589,409

1.90 × 10−10

5.06 × 10−3

3.10 × 10− 11

Intron

ZFPM2

rs10883944

10

21

chr10:105522875–105,667,110

7.80 × 10−9

2.11 × 10−4

2.33 × 10−10

Intron

OBFC1, SH3PXD2A

rs4746139

10

92

chr10:75404300–75,692,923

4.50 × 10−10

9.94 × 10−3

1.60 × 10− 10

Synonymous

AGAP5, BMS1P4, C10orf55, CAMK2G, CHCHD1, FUT11, GLUD1P3, NDST2, PLAU, SEC24C, SYNPO2L, ZSWIM8, ZSWIM8-AS1

rs2512519

11

68

chr11:77924870–78,286,462

2.10 × 10− 10

2.32 × 10−3

4.39 × 10−12

Intron

GAB2, NARS2, USP35

rs8756

12

12

chr12:66306441–66,389,968

2.20 × 10−11

3.22 × 10−3

2.57 × 10− 12

3′ UTR

HMGA2

rs56386186

14

77

chr14:102418380–102,784,274

1.70 × 10−10

2.79 × 10−3

1.22 × 10−11

Intron

DYNC1H1, HSP90AA1, MOK, WDR20, ZNF839

rs7143026

14

17

chr14:65825854–66,272,664

1.90 × 10−6

1.22 × 10−4

2.54 × 10−8

Intergenic

FUT8, FUT8-AS1

rs754388

14

34

chr14:93068516–93,118,229

3.0 × 10−4

7.07 × 10−12

1.03 × 10−11

Intron

RIN3

rs17186681

15

138

chr15:63800237–64,148,582

2.50 × 10−11

6.57 × 10−3

1.50 × 10−12

Intron

FBXL22, HERC1, USP3, USP3-AS1

rs17431820

16

10

chr16:64939145–65,128,819

5.30 × 10−12

9.78 × 10−3

2.38 × 10− 12

Intron

CDH11

rs12709669

18

14

chr18:19780858–19,826,742

4.10 × 10−9

4.80 × 10−3

8.11 × 10−10

Intron

GATA6

  1. SNP single nucleotide polymorphisms, CHR chromosome, N number of SNPs clumped with peak variant, RHR resting heart rate, COPD chronic obstructive pulmonary disease