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Fig. 1 | Respiratory Research

Fig. 1

From: Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis

Fig. 1

Overall study design. Multiple GWAS data sources were first retrieved. We first conducted genome-wide genetic correlation between COPD and 4 major cardiovascular disease (CVD) traits. For CVD traits that were shown genetic correlation with COPD, we conducted further post-GWAS analyses to investigate genetic overlap between them (variant/region/functional levels, smoking effect and causal inference). We also evaluated the genetic correlation between COPD and other CVD related traits. Abbreviations: ICGC: International COPD Genomic Consortium; UKBB: UK Biobank; ISGC: International Stroke Genetics Consortium; GIANT: The Genetic Investigation of ANthropometric Traits (GIANT) consortium; DIAGRAM: DIAbetes Genetics Replication And Meta-analysis consortium; ENGAGE: European Network for Genetic and Genomic Epidemiology consortium; TAG: Tobacco and Genetics Consortium

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