Fig. 1
From: Salicylic acid amplifies Carbachol-induced bronchoconstriction in human precision-cut lung slices
Salicylic acid enhances carbachol-induced bronchoconstriction in hPCLS. Precision-cut human lung slices (hPCLS) from normal human lung donors were exposed to salicylic acid (SA, vehicle F-12 medium) or toluene diisocyanate (TDI, vehicle 0.1% ethanol) for 24 h, followed by a carbachol (CCh) concentration-response for bronchoconstriction. a & b) SA (10 uM) significantly increased CCh-induced bronchoconstriction (n = 4–5 donors, Log EC50, *p = 0.04 Veh vs SA 10 uM). e-h) TDI has no significant effect on CCh-induced bronchoconstriction (n = 3–6 donors, Log EC50, p = 0.4 Veh Vs TDI 1 uM)