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Table 4 Cox regression using cut-off levels for C4Ma3 and fibrinogen

From: Type IV collagen turnover is predictive of mortality in COPD: a comparison to fibrinogen in a prospective analysis of the ECLIPSE cohort

Parameter

Hazard ratio (95% CI)

P value

Model 1 (high C4Ma3)

 High C4Ma3

5.12 (2.28–11.50)

0.0001

 Age

1.11 (1.03–1.19)

0.0051

 Former smoking

5.54 (1.30–23.60)

0.0206

Model 2 (high Fibrinogen)

 Age

1.10 (1.03–1.19)

0.0079

 Former smoking

4.82 (1.12–20.65)

0.0342

 mMRC dyspnea score

1.45 (1.03–2.04)

0.0334

Model 3 (high C4Ma3 and high Fibrinogen)

 High C4Ma3

3.75 (1.60–8.80)

0.0024

 Age

1.09 (1.02–1.17)

0.0145

 Former smoking

5.03 (1.17–21.62)

0.0301

  1. Cox proportional hazards regression, enter method. Parameters tested for inclusion in all the models: High biomarker level; Age; smoking status; prior hospitalized acute exacerbations; mMRC modified Medical Research Council dyspnea score and 6MWD 6-min walk distance