Body composition, muscle function, and physical performance in fibrotic interstitial lung disease: a prospective cohort study

Table 4 Unadjusted and adjusted correlation of ILD severity with physical performance

	Unadjusted analysis				Adjusted for sex, age, weight, SMI, % body fat
	Men		Women		Adjusted for sex, age, weight, SMI, % body fat
	r	p-value	r	p-value	Coefficient (95% CI)	p-value	R²
Grip strength, kg
FVC, %-predicted	0.17	0.16	− 0.13	0.41	0.050 (− 0.022 to 0.122)	0.17	0.65
DLCO, %-predicted	0.16	0.21	0.22	0.20	0.115 (0.026 to 0.204)	0.01	0.67
CPI	−0.29	0.03	− 0.31	0.08	− 0.140 (− 0.247 to − 0.034)	0.01	0.66
Dyspnea (UCSD SOBQ)	−0.08	0.58	−0.07	0.71	−0.066 (− 0.122 to − 0.010)	0.02	0.68
Gait speed, m/s
FVC, %-predicted	0.35	0.003	0.16	0.30	0.004 (0.001 to 0.007)	0.01	0.10
DLCO, %-predicted	0.25	0.049	0.06	0.71	0.004 (0.0005 to 0.008)	0.03	0.07
CPI	−0.29	0.02	−0.06	0.72	−0.006 (− 0.011 to − 0.002)	0.009	0.08
Dyspnea (UCSD SOBQ)	− 0.28	0.04	− 0.49	0.003	− 0.005 (− 0.007 to − 0.002)	0.0003	0.16

Coefficients are reported per one-unit change for the predictor variables. A positive coefficient indicates an increase in the outcome variable per unit of the predictor variable (e.g., grip strength increases by an average of 0.115 kg for every 1% increase of DLCO %-predicted)
Abbreviations: CI confidence interval, CPI composite physiologic index, DLCO diffusion capacity of the lung for carbon monoxide, FVC forced vital capacity, r Pearson’s correlation coefficient, R² coefficient of determination (variability in the outcome explained by the model), SMI skeletal muscle index, UCSD SOBQ University of California San Diego Shortness of Breath Questionnaire

ISSN: 1465-993X