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Table 4 Unadjusted and adjusted correlation of ILD severity with physical performance

From: Body composition, muscle function, and physical performance in fibrotic interstitial lung disease: a prospective cohort study

  Unadjusted analysis Adjusted for sex, age, weight, SMI, % body fat
Men Women
r p-value r p-value Coefficient (95% CI) p-value R2
Grip strength, kg
 FVC, %-predicted 0.17 0.16 − 0.13 0.41 0.050 (− 0.022 to 0.122) 0.17 0.65
 DLCO, %-predicted 0.16 0.21 0.22 0.20 0.115 (0.026 to 0.204) 0.01 0.67
 CPI −0.29 0.03 − 0.31 0.08 − 0.140 (− 0.247 to − 0.034) 0.01 0.66
 Dyspnea (UCSD SOBQ) −0.08 0.58 −0.07 0.71 −0.066 (− 0.122 to − 0.010) 0.02 0.68
Gait speed, m/s
 FVC, %-predicted 0.35 0.003 0.16 0.30 0.004 (0.001 to 0.007) 0.01 0.10
 DLCO, %-predicted 0.25 0.049 0.06 0.71 0.004 (0.0005 to 0.008) 0.03 0.07
 CPI −0.29 0.02 −0.06 0.72 −0.006 (− 0.011 to − 0.002) 0.009 0.08
 Dyspnea (UCSD SOBQ) − 0.28 0.04 − 0.49 0.003 − 0.005 (− 0.007 to − 0.002) 0.0003 0.16
  1. Coefficients are reported per one-unit change for the predictor variables. A positive coefficient indicates an increase in the outcome variable per unit of the predictor variable (e.g., grip strength increases by an average of 0.115 kg for every 1% increase of DLCO %-predicted)
  2. Abbreviations: CI confidence interval, CPI composite physiologic index, DLCO diffusion capacity of the lung for carbon monoxide, FVC forced vital capacity, r Pearson’s correlation coefficient, R2 coefficient of determination (variability in the outcome explained by the model), SMI skeletal muscle index, UCSD SOBQ University of California San Diego Shortness of Breath Questionnaire