Fig. 10

Effect of RASEF overexpression on cigarette smoke -induced AKT activation. a Transfection of HPASMCs with Ad.RASEF prevented 48-h CSE-induced increases in phospho-AKT (Ser473), PCNA, and MMP9 protein levels. b Protein expressions of RASEF, MMP9, and P-AKT (ser-473) in rat PAs were examined by immunochemistry. Scale bar = 50 μm