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Table 6 Responsiveness: mean change of QOL in changed health status in anchor; significant changes of QOL confirm responsiveness

From: Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis

Improvement in the specific anchor
  FVC DLCO 6MWD SF-36 item TDI NYHA
na 9–11 10–11 14–17 10–15 15–16 18–19
  mean sd mean sd mean sd mean sd mean sd mean sd
PSC 6.2* 6.5 −3.9 9.6 3.0 10.5 4.0 10.1 4.3* 11.1 1.8 9.4
MSC −3.6 13.1 −1.8 10.5 −1.1 10.2 −0.7 9.0 −0.7 8.3 −1.4 7.3
PFI 15.3 24.0 −3.9 19.9 1.6 19.7 5.4* 11.7 5.5 18.9 −3.2 24.1
ROLEM −16.7 72.4 0.0 64.8 −8.9 47.9 0.0 62.9 −6.3 42.5 −20.4* 36.4
ROLPH 17.5 39.2 −25.0 45.6 11.7 28.1 30.0 55.0 20.3 44.0 2.8 34.2
GHP 7.1 20.8 −11.9* 14.6 2.3 14.5 4.1 24.2 5.0 22.8 2.6 19.4
MHI 2.0 19.0 −4.2 10.2 3.2 11.7 −1.0 9.6 1.9 16.7 1.7 11.7
VITAL 4.5 12.8 −2.3 14.0 4.4 13.4 4.0 16.5 7.4 14.8 1.1 14.1
SOCIAL 1.1 30.8 −10.2* 9.4 0.0 15.3 1.8 18.9 3.1 23.0 6.6 21.0
PAIN 0.2 31.9 4.9 23.9 11.5 28.8 1.3 23.8 −0.3 36.1 6.9 29.6
deterioration in the specific anchor
  FVC DLCO 6MWD SF-36 item TDI NYHA
na 30–36 22–28 29–36 37–45 55–73 29–40
  mean sd mean sd mean sd mean sd mean sd mean sd
PSC −2.6 10.3 −5.0 10.4 −2.8* 8.5 −3.0* 9.5 −2.4 7.8 −1.1 9.0
MSC −2.9 13.0 −2.8 10.0 0.1 9.6 −3.0* 9.5 −0.7 8.3 −1.0 11.0
PFI −12.9* 23.8 −14.1* 25.0 −9.3* 21.4 −10.2* 22.3 −3.9 21.3 − 2.7 25.2
ROLEM −7.3 62.1 −15.9 49.1 −3.1 44.3 −4.4 48.5 −1.7 37.9 2.2 57.7
ROLPH −2.3 51.7 −15.0 36.8 −14.5* 33.0 −10.1 35.8 −9.0* 35.7 −4.9 39.6
GHP −7.3* 17.1 −6.9 16.8 −2.3 17.4 −5.0 15.0 −4.8* 13.8 −6.7 17.1
MHI −8.1 17.2 −4.4 17.3 −2.1 14.5 −5.8 17.3 −4.1* 13.5 −3.3 17.7
VITAL −8.2* 18.8 −3.7 22.0 −3.0 15.7 −6.8* 15.0 −4.7* 15.8 −0.4 19.3
SOCIAL −10.8* 29.6 −12.9* 25.6 −7.3 30.5 − 13.3* 24.8 −1.5 23.2 − 14.1* 32.2
PAIN −3.1 32.6 −10.0 35.1 4.6 27.4 −3.3 37.9 −2.7 27.3 −8.1 31.0
  1. a sample size varying depending on temporal relation of anchors and filled in SF-36, number of missing items within SF-36 and the possibility to calculate dimensions and summary scores
  2. SD standard deviation
  3. *p < 0.05
  4. **p < 0.001
  5. Abbreviations: PCS Physical component score, MCS Mental component score, GHP General health perceptions, PFI Physical functioning, ROLPH physical role functioning, ROLEM emotional role functioning, SOCIAL Social role functioning, MHI Mental health, PAIN bodily pain, VITAL vitality, sd standard deviation, FVC Forced vital capacity, DLCO Diffusing capacity of the lungs for carbon monoxide, 6MWD 6 min walking distance, SF-36 item indicating health status of the last year, TDI Transitional Dyspnoea Index, NYHA New York Heart Association