Table 3 Clinical factors associated with all-cause mortality in men and women patients (univariate analysis)

Age, yr

1.033 (1.001–1.064)

0.037

1.012 (0.978–1.047)

0.507

1.098 (1.036–1.164)

0.002

Sex, Female

1.031 (0.581–1.831)

0.916

BMI, kg/m²

0.900 (0.833–0.971)

0.007

0.861 (0.789–0.938)

0.001

1.044 (0.895–1.219)

0.583

Smoking history, pack-years

1.004 (0.993–1.015)

0.488

1.005 (0.994–1.016)

0.406

0.757 (0.259–2.211)

0.610

Diabetes, n

1.495 (0.922–2.425)

0.103

1.275 (0.731–2.222)

0.392

2.521 (0.907–7.012)

0.076

Use of Statins or Sulfonylureas or Glinides, n

0.962 (0.588–1.576)

0.879

0.944 (0.538–1.655)

0.840

0.964 (0.341–2.725)

0.945)

FVC % predicted

0.958 (0.944–0.973)

< 0.001

0.961 (0.945–0.977)

< 0.001

0.943 (0.907–0.982)

0.004

FEV1, % predicted

0.973 (0.960–0.986)

< 0.001

0.975 (0.961–0.989)

0.001

0.964 (0.932–0.996)

0.030

DLCO % predicted

0.972 (0.959–0.985)

< 0.001

0.969 (0.955–0.984)

< 0.001

0.975 (0.938–1.012)

0.183

TLC, % predicted

0.970 (0.950–0.990)

0.004

0.970 (0.950–0.990)

0.004

0.944 (0.882–1.009)

0.091

^aT4 level muscle index, cm²/m²

0.965 (0.937–0.993)

0.015

0.958 (0.926–0.991)

0.013

0.972 (0.904–1.044)

0.433

^bT12 level muscle index, cm²/m²

0.910 (0.841–0.984)

0.019

0.908 (0.831–0.992)

0.033

0.917 (0.772–1.089)

0.322

GAP Score

1.356 (1.137–1.619)

0.001

1.366 (1.112–1.678)

0.003

1.403 (0.977–2.014)

0.067