Skip to main content

Table 3 Summary of the PK Parameters of AZD7594 at Steady‐State (Day 14) by Dose Levels

From: Efficacy and safety of AZD7594, an inhaled non-steroidal selective glucocorticoid receptor modulator, in patients with asthma: a phase 2a randomized, double blind, placebo-controlled crossover trial

Geometric mean

AZD7594

AZD7594

AZD7594

(CV%)

58 μg

250 μg

800 μg

(n = 9)

(n = 9)

(n = 8)

Cmax, ss (pmol/L)

54.97 (19.70)

158.7 (35.01)

421.6 (37.26%)

AUC(0‐24) (h×pmol/L)

467.1 (17.91)

1725 (44.33)

4894 (52.48%)

Cavg, ss (pmol/L)

19.48 (17.93)

71.89 (44.33)

203.9 (52.55%)

  1. AUC(0‐24): area under the plasma concentration‐time curve from time zero to 24 hours after dose administration; Cavg,ss: average plasma concentration during a dosing interval at steady‐state; Cmax,ss: observed maximum plasma concentration at steady‐state; CV%: geometric coefficient of variation; n: number of patients in the PKS for each treatment