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Table 1 Patients characteristics

From: Effect of COPD severity and comorbidities on the result of the PHQ-9 tool for the diagnosis of depression: results from the COSYCONET cohort study

 

GOLD grades

p value

GOLD groups based on mMRC for differentiation between A/C and B/D

p value

total (n = 2255)

GOLD 1 (=203)

GOLD 2 (n = 948)

GOLD 3 (n = 863)

GOLD 4 (n = 241)

GOLD A (n = 871)

GOLD B (n = 567)

GOLD C (n = 294)

GOLD D (n = 523)

Gender (m/f)

122/81

573/375

525/338

156/85

0.657

548/323

352/215

175/119

301/222

0.212

1376/879

Age (y) ± SD

66.1 ± 8.7

65.7 ± 8.4

65.0 ± 8.2

62.2 ± 7.9

< 0.001*

65.1 ± 8.5

66.2 ± 8.1

63.7 ± 9.0

64.6 ± 8.0

< 0.001*

65.1 ± 8.4

BMI (kg/m2)

26.7 ± 4.6

27.4 ± 5.1

26.5 ± 5.4

24.4 ± 5.0

< 0.001*

26.2 ± 4.6

27.5 ± 5.6

25.8 ± 4.5

27.0 ± 6.0

< 0.001*

26.7 ± 5.2

Pack years

44.8 ± 31.2

50.9 ± 37.5

48.4 ± 34.8

48.5 ± 33.5

0.156

47.6 ± 34.4

53.0 ± 36.9

45.0 ± 33.1

49.9 ± 36.8

0.009*

49.1 ± 35.5

Smoking status active /not active

62/141

271/677

188/675

35/206

< 0.001*

260/581

130/437

73/221

93/430

< 0.001*

556/1699

FEV1 (% predicted)

88.7 ± 8.1

62.6 ± 8.3

40.7 ± 5.6

24.8 ± 3.9

< 0.001*

61.3 ± 18.0

47.6 ± 16.6

54.2 ± 16.9

42.4 ± 15.2

< 0.001*

52.5 ± 18.6

CAT

14.2 ± 6.8

16.9 ± 7.1

19.4 ± 7.2

22.1 ± 6.8

< 0.001*

13.9 ± 6.2

20.3 ± 6.2

16.7 ± 6.3

23.7 ± 6.3

< 0.001*

18.1 ± 7.4

mMRC

1.0 ± 0.7

1.3 ± 0.8

1.9 ± 0.9

2.3 ± 0.9

< 0.001*

0.9 ± 0.4

2.4 ± 0.5

0.9 ± 0.4

2.5 ± 0.6

< 0.001*

1.6 ± 0.9

EQ-5D-VAS

67.2 ± 16.9

61.6 ± 18.0

52.7 ± 18.0

46.7 ± 17.0

< 0.001*

67.0 ± 16.8

50.3 ± 16.1

62.4 ± 15.4

45.2 ± 16.3

< 0.001*

57.2 ± 18.8

PHQ-9 Sum score

5.6 ± 4.2

6.0 ± 4.5

6.5 ± 5.0

7.0 ± 5.1

0.002*

4.5 ± 3.7

7.1 ± 4.8

5.9 ± 4.1

8.6 ± 5.2

< 0.001*

6.3 ± 4.7

PHQ-9 ≥ 10 (major depression)%

33 (16.3)

182 (19.2)

201 (23.3)

68 (28.2)

0.002*

88 (10.1)

151 (26.6)

45 (15.3)

200 (38.2)

< 0.001*

484/1771

  1. The table shows mean values (± standard deviations), for gender, smoking status and PHQ-9 values≥10 absolute numbers (percentages). The comparisons of age, BMI, smoking history in terms of pack-years and lung function between GOLD 1–4 and A-D were performed by unadjusted analysis of variance; gender was compared by the chi-squared statistics. BMI body-mass index, FEV1 forced expiratory volume in 1 s, CAT COPD assessment test, mMRC modified Medical Research Council scale, smoking status = active smoking was defined as regular or occasional active cigarette smoking within the last 4 weeks prior to the interview, not active as smoking included former smokers defined as regular or occasional active cigarette smoking in the past, as well as never smokers defined as no active cigarette smoking over lifetime *p < 0.05. For GOLD grades 1–4 the p-values refer to the comparisons of all four grades, for groups A-D the p-values refer to the comparisons of all four groups
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Respiratory Research

ISSN: 1465-993X

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