Fig. 7
From: Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling
EP treatment reduces ODE exposure induced secretion of GM-CSF and IL-1β but not IL-8 and IL-6 levels. Compared to medium (controls, 0 h), ODE treated BEAS-2B cells secreted increased levels of GM-CSF, IL-1β, IL-8 and IL-6 (a-d) respectively. Compared to vehicle (Ringer’s solution), co-treatment with EP (2.5 μM) significantly reduced ODE-induced GM-CSF and IL-1β levels (a and b). Data (n = 6) analyzed using two-way ANOVA is represented. * or # p < 0.05, ** or ## p < 0.01, *** or ### p < 0.001, **** or #### p < 0.0001. # indicates different from control whereas * indicates difference within the OD/barn exposure groups