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Fig. 3 | Respiratory Research

Fig. 3

From: Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling

Fig. 3

EP reduces ODE-exposure induced nucleocytoplasmic translocation of HMGB1. Medium (control, 0 h) or ODE (6, 24 and 48 h post) treated cells were stained with polyclonal anti-HMGB1 antibody and DAPI stain delineated the nuclei. Compared to controls, ODE treated cells showed nucleocytoplasmic translocation of HMGB1 (arrows and inset, bar = 200 μm, a). Compared to vehicle (medium), co-treatment with EP (2.5 μM) showed a marked decrease in ODE-induced nucleocytoplasmic translocation of HMGB-1 (arrows and inset, micrometer = 200 μm, b)

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