Fig. 2
From: Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling
OD exposure of rats in the swine barn work environment and HMGB1 expression. Immunohistochemical staining for HMGB1 expression was performed on rat lung tissues. Compared to controls, one, five and 20-day barn (organic dust) exposure of rats induced an increase in the expression of HMGB1 in the bronchioles, alveolar septa and BALT (a) and endothelium of the blood vessels and ASM (arrows and inset, bar = 100 μm, e), respectively. One-way ANOVA performed on immunohistochemical scores for HMGB1 expression in bronchioles (9 fields/animal), alveolar septa (5 fields/animal) and BALT (7 fields/animal) (b-d) and endothelium of blood vessels (3 fields/animal) and ASM (11 fields/animal) is presented (f and g). *p < 0.05, **p < 0.005, ***p < 0.0005, ****p < 0.0001