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Fig. 4 | Respiratory Research

Fig. 4

From: BAMBI regulates macrophages inducing the differentiation of Treg through the TGF-β pathway in chronic obstructive pulmonary disease

Fig. 4

Overexpression of BAMBI facilitates the conversion of M2 to M1 cells through the TGF- β/SMAD signalling pathway. a. Transfection of pCMV-BAMBI into macrophages was validated by RT-PCR and WB. GAPDH was used as an endogenous control. b. Change in the phenotype characteristic between the BAMBI-upregulated macrophage (BUM) group and M2 macrophage group. c. The ability to induce the differentiation of CD4+ naïve T cells to Tregs in the BUM group and M2 cell group. d. Concentration of TGF-β1 in the BUM group and M2 cell group. e. The protein expression levels of TGF-βRI, TGF-βRII and p-SMAD2/3 in BUM group and M2 cell group. *P < 0.05, ***P < 0.001

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Respiratory Research

ISSN: 1465-993X

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