TY - JOUR AU - Huang, Li AU - Duan, Shuyin AU - Shao, Hua AU - Zhang, Aihua AU - Chen, Shuang AU - Zhang, Peng AU - Wang, Na AU - Wang, Wei AU - Wu, Yongjun AU - Wang, Jing AU - Liu, Hong AU - Yao, Wu AU - Zhang, Qiao AU - Feng, Feifei PY - 2019 DA - 2019/01/29 TI - NLRP3 deletion inhibits inflammation-driven mouse lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide JO - Respiratory Research SP - 20 VL - 20 IS - 1 AB - Inflammatory micro-environment has been proposed to play a critical role in lung tumorigenesis. NLRP3 is known as an intracellular receptor involving inflammation and has been reported which is increasingly associated with tumor development, but the role in inflammation-driven lung cancer has not been fully clarified. In this study, we investigated whether lipopolysaccharide (LPS)-induced pulmonary inflammation could contribute to lung tumorigenesis induced by benzo(a)pyrene [B(a)p] in C57BL/6J mice and the role of NLRP3 in the pathogenesis. SN - 1465-993X UR - https://doi.org/10.1186/s12931-019-0983-4 DO - 10.1186/s12931-019-0983-4 ID - Huang2019 ER -