Skip to main content

Table 2 Knowledge advancement on the topic

From: Porcine vs bovine surfactant therapy for preterm neonates with RDS: systematic review with biological plausibility and pragmatic meta-analysis of respiratory outcomes

Outcome

Cochrane Meta-analysis 2015 [9]a

Present work

 Mortality

Favours poractant-α (for some types of mortality)b

Trend favouring poractant-α

 BPD

No difference

Favours poractant-α

 Airleaks

No difference

Favours poractant-α

 Lung haemorrhage

No difference

Favours poractant-α

 BPD/mortality

Favours poractant-α

Favours poractant-α

 Re-treatment

Unknown or favours poractant-αc

Favours poractant-α

Effect of confounder

Cochrane Meta-analysis 2015

Present work

 Prenatal steroids

Unknown

Not significant

 Gestational age

Unknown

Influences effect size on BPD and need for retreatment

 Poractant-α dose

Unknown

Unknown

  1. Conclusions from the present work and the earlier meta-analysis [9] are compared. New insights are in italic texts
  2. aincluding both the comparisons lavage bovine and minced bovine vs minced porcine surfactant - b only for in-hospital mortality. The overall neonatal mortality did not present any difference - c This outcome was analysed only for the comparison bovine minced vs porcine minced surfactants