Table 1 Biochemical and pharmacological data of all current animal-derived surfactant preparations
Biochemical (trade) name | Preparation method | Total PL (mg/mL) | Main PL° | SP-B ∫ (mg/mL) | SP-C ∫ (mg/mL) | Dose # (mg/mL) | Volume (mL/kg) | |
|---|---|---|---|---|---|---|---|---|
Bovine | Beractant (Survanta®) | Enriched minced lung† | 25 | DPPC (70%) and PS (4%) | 0.03 | 0.3 | 100 | 4 |
BLES (Neosurf® or Liposurf®) | Lung lavage | 27 | DPPC (42%) and PG (11%) | 0.17 | 0.49 | 135 | 5 | |
Bovactant (Alveofact®) | Lung lavage | 45 | DPPC (39%) and PG (8.5%) | 0.3 | 0.7 | 50 | 1.2 | |
Calfactant (Infasurf ®) | Lung lavage (from calves) | 35 | DPPC (41%) and PG (6%) | 0.26 | 0.36 | 105 | 3 | |
Calf Pulmonary Surfactant for Injection (Kelisu®) $ | Lung lavage (from calves) | 30 | DPPC 48% other data n.a. | 0.2 | 0.25 | 100 | 3.3 | |
Korean bovine surfactant (Newfactan ®) | Minced lung | 25 | DPPC (60%) and PG (6%) | @ | @ | 120 | 4.8 | |
Surfactant-TA (Surfacten®) | Enriched minced lung† | 25 | DPPC (65%) other data n.a. | n.a. | n.a. | 120 | 4.8 | |
Porcine | Butantan$ | Minced lung | 25 | DPPC (76%) and PE (7%) | ^ | ^ | 100 | 4 |
Poractant-α (Curosurf ®) | Modified minced lung* | 80 | DPPC (46%) and PE (6%) | 0.45 | 0.9 | 100 or 200 | 1.25 or 2.5 | |
Surfacen$ | Lung lavage | 25 | DPPC (45%) and PI (12%) | π | π | 100 | 4 |