Table 1 Characteristics of the 3 cohorts (4 transcriptomic datasets)

Sample Type and GEO accession number

Lung Tissue

Lung Tissue

Sputum & Blood

p value

GSE69818

GSE76925

GSE22148, GSE76705

Number of COPD/Controls

70/0

90 /34

121/0

Gender (M/F)

63/7

57/67

81/40

0.0005

Age

66.3 ± 8.6

64.3 ± 7.3

65.1 ± 5.5

ns

Current/Former Smokers

0/70

0/124

0/121

ns

Pack-years of smoking

56.5 ± 26.1

57.2 ± 28.6

47.1 ± 29.2

0.012

BMI

27.5 ± 4.5

26.2 ± 4.6

26.6 ± 4.9

ns

FEV₁% predicted

57.9 ± 21.1

46.1 ± 34.0

48.9 ± 15.1

< 0.0001

FEV₁/FVC

52.8 ± 12.3

45.1 ± 22.8

42.6 ± 11.8

0.0075