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Table 1 The L/BW ratio and serum parameters as adverse effects of RXR agonists

From: A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation

  PBS/vehicle PPE/vehicle PPE/NEt-4IB
0.015%
PPE/Bexarotene
0.015%
L/BW ratio 0.050 ± 0.002 0.049 ± 0.001 0.053 ± 0.001# 0.073 ± 0.002*, #, ##
TG (mg/dl) 173 ± 12 140 ± 11* 177 ± 11# 255 ± 17*, #, ##
Glucose (mg/dl) 482 ± 23 479 ± 21 565 ± 35 492 ± 30
AST (IU/L) 125 ± 13 151 ± 12 153 ± 19 123 ± 12
ALT (IU/L) 56 ± 9 66 ± 7 54 ± 5 31 ± 4*, #, ##
ALP (IU/L) 275 ± 10 303 ± 9 296 ± 6 406 ± 11*, #, ##
LAP (IU/L) 54 ± 2 51 ± 1 53 ± 1 52 ± 1
AMY (IU/L) 5352 ± 509 4608 ± 276 5155 ± 445 6049 ± 204#
  1. *Significant differences (P < 0.05) between PBS/vehicle and PPE/vehicle or PPE/Bexarotene 0.015%. #Significant differences (P < 0.05) between PPE/vehicle and PPE/NEt-4IB 0.015% or PPE/bexarotene 0.015%. ##Significant differences (P < 0.05) between PPE/NEt-4IB 0.015% and PPE/bexarotene 0.015%