Table 6 Survival analyses showing time to primary endpoints outcome (all-cause mortality) and secondary endpoints (respiratory specific mortality and respiratory hospitalisation) in a time-dependent multivariate analyses

A → A

1.00 ref

1.00 ref

1.00 ref

A → BC

1.66 (1.34–2.07)

<.0001

2.28 (1.50–3.46)

0.0001

1.62 (1.31–2.01)

<.0001

A → D

2.08 (1.30–3.32)

0.0022

4.68 (2.37–9.23)

<.0001

3.13 (2.13–4.60)

<.0001

BC → A

1.58 (1.23–2.02)

0.0003

2.27 (1.43–3.60)

0.0005

1.44 (1.13–1.83)

0.0034

BC → BC

1.98 (1.67–2.35)

<.0001

3.27 (2.34–4.55)

<.0001

2.32 (1.97–2.73)

<.0001

BC → D

3.21 (2.61–3.94)

<.0001

7.51 (5.30–10.66)

<.0001

4.81 (3.98–5.82)

<.0001

D → A

1.31 (0.61–2.78)

0.4890

0.79 (0.11–5.70)

0.8112

1.01 (0.42–2.46)

0.9755

D → BC

2.96 (2.32–3.78)

<.0001

7.38 (4.99–10.93)

<.0001

4.12 (3.29–5.17)

<.0001

D → D

4.31 (3.64–5.10)

<.0001

12.86 (9.47–17.46)

<.0001

5.87 (4.97–6.92)

<.0001