Skip to main content

Table 1 Baseline characteristics of the study cohort

From: Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study)

   Mean ± standard deviation or n and (%) 95% CI (mean) median and interquartile ranges
Variable N lower limit upper limit
Demographics
 Age [years] 71 59.1 ± 13.42 56.0 62.3 60 [50; 71]
 Height [cm] 71 167.6 ± 9.89 165.2 169.9 168 [160; 174]
 Weight [kg] 71 76.91 ± 17.53 72.77 81.06 73.0 [65; 87]
 BMI [kg/m2] 71 27.26 ± 5.04 26.06 28.45 26.42 [24; 29.05]
 gender [female n (%)]   38 (53.5%)    
Pulmonary hypertension etiology
 Idiopathic PAH   14 (19.7%)    
 CTD-APAH   10 (14.1%)    
 Other PAH   8 (11.3%)    
 Chronic thromboembolic pulmonary hypertension   39 (54.9%)    
WHO functional class
 II   17 (23.9%)    
 III   54 (76.1%)    
Pulmonary hypertension targeted treatment
 treatment naÏve   52 (73%)    
 Endothelin-Receptor-Antagonist   14 (20%)    
 Phosphodiesterase-5-inhibitor   5 (7%)    
 Oxygen   7 (10%)    
Vital signs
 Systolic Blood Pressure [mmHg] 71 114.3 ± 12.90 111.2 117.3 110 [105; 123]
 Diastolic Blood Pressure [mmHg] 71 72.0 ± 9.93 69.6 74.3 70 [65; 80]
 Heart Rate [bpm] 71 80.6 ± 9.99 78.2 83.0 80 [72; 88]
Clinical parameters
 NTproBNP [pmol/L] 41 140.97 ± 230.87 68.10 213.84 43.3 [18.1; 175.5]
 6-min walking distance [meters] 68 359.0 ± 91.48 336.9 381.1 359 [295; 419]
Hemodynamics measured by right heart catheter
 mean PAP [mmHg] 45 46.13 ± 9.833 43.17 49.08 46.0 [39; 54]
 Pulmonary Vascular Resistance [dyn*sec*cm−5] 45 700.75 ± 282.82 615.79 785.72 593.6 [510.6; 829]
 Cardiac Index [L/min/m2] 45 2.53 ± 0.46 2.39 2.66 2.58 [2.31; 2.78]
 Cardiac Output [L/min] 45 4.69 ± 1.06 4.37 5.01 4.6 [4.3; 5.2]
 Pulmonary Arterial Wedge Pressure [mmHg] 45 7.4 ± 2.85 6.5 8.2 7 [5; 8]
  1. CI confidence interval, BMI Body mass index, PAH pulmonary arterial hypertension, CTD connective tissue disease
  2. NTproBNP fragment of N-terminal pro brain natriuretic peptide, PAP pulmonary arterial pressure