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Fig. 9 | RESPIRATORY RESEARCH

Fig. 9

From: LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension

Fig. 9

H19 knockout protects mice from pulmonary artery remodeling and PAH. After WT and H19−/− mice were injected with saline or MCT (600 mg/kg) continuously for 8 weeks, RVSP was detected (a, b). c: The ratio of RV/ (LV + S). d: H&E staining and immunohistochemical staining of α-smooth muscle actin were performed in the lung sections. Representative images of pulmonary small arteries. Scale bar = 50 μm. Quantification of wall thickness (e) and vessel muscularization (f). Values were presented as means ± SD (n = 6 in each group). Only vessels with diameter between 30 and 90 μm were analyzed. NM, nonmuscularized vessels; PM, partially muscularized vessels; FM, fully muscularized vessels. ***P < 0.001 (different from the corresponding control). ##0.001 ≤ P ≤ 0.009 [RV/ (LV + S) or PM in H19−/−-MCT group vs. WT-MCT group]; ###P < 0.001 [RVSP, wall thickness (%), NM or FM in H19−/−-MCT group vs. WT-MCT group]

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