Table 3 Regulatory variants (eQTLs) in LD with asthma-associated variants
From: Identification of deleterious and regulatory genomic variations in known asthma loci
eQTL | Affected Gene(s) | Tissue | Affected Binding Motif(s) | Asthma Variant(s) in LD |
|---|---|---|---|---|
rs14078 | NPPA | Lymphoblastoid | C/EBP | rs5065 |
rs17032120 | UNC50 | Monocytes | Whn | rs2278206 |
rs3769737 | UNC50 | Monocytes | Gm12892, Hsmm, Hsmmt, Huh7 | rs2278206 |
rs17446058 | UNC50 | Monocytes | deltaEF1 | rs2278206 |
rs5743563 | TLR10, TLR1, TLR6 | Lymphoblastoid | YY1 | rs4129009, rs4833095 |
rs5743565 | TLR10, TLR6, TLR1 | Lymphoblastoid | GATA-4 | rs4129009, rs4833095 |
rs7941648 | RPS6KB2 | Lymphoblastoid | CDP, BCL6, Foxd3, Sox7, Sox18, Sry, Sox5 | rs1695, rs6591255 |
rs12654778 | ADRB2 | Lymphoblastoid | TP53 | rs1042713 |
rs10039559 | RAD50 | Lymphoblastoid | C/EBP | rs11745587 |
rs204992 | HLA-DQA1 | Lymphoblastoid | CAC-bindingprotein | rs204993 |
rs3131294 | HLA-DQA1, HLA-C, HLA-DQB1, HLA-DRB1, HLA-DRB5, HLA-DRA, ERG a , HCG27, HLA-C, LIMS1 a | Lymphoblastoid, Monocytes | AIRE | rs3135388 |
rs6928482 | HLA-DQA1, HLA-DQA2 | Lymphoblastoid | Zfp410 | rs3104367, rs9272346, rs9273373 |
rs1063355 | HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRA | Lymphoblastoid | Isgf3g | rs3104367, rs9272346, rs9273373 |
rs2076523 | HLA-DQA2, HLA-DQB1, HLA-DQA2 | Lymphoblastoid | Hepg2 | rs9268516 |
rs2213585 | HLA-DQB1, HLA-DRB1, HLA-DRB5, HLA-DRA, HLA-DQA1 | Lymphoblastoid | Zfp410 | rs3129890 |
rs6906021 | POLR2A, TAF1, PAX5 | Lymphoblastoid | Pit-1 | rs3104367, rs9272346, rs9273373 |
rs7970524 | HAL, LTA4H | Monocytes | AR | rs2540493 |
rs12429692 | ALOX5AP | Monocytes | PU.1 | rs10507391 |
rs3862469 | DEXI, LOC642755 a | Monocytes | NF-E2, ZBRK1, MAFB | rs9923856 |
rs11642631 | DEXI, LOC642755 a | Monocytes | VDR | rs9923856 |
rs12946510 | KRT222P, MEd24, NR1D1, ORMDL3 | Lymphoblastoid | FOXO1, IRF1, Srf, Elf3 | rs907092, rs4795397, rs11655198, rs2305480, rs62067034, rs11078927, rs2290400, rs7216389, rs4794820, rs12450323 |
rs8076131 | KRT222P, NR1D1, ORMDL3 | Lymphoblastoid | Tcfe2a | rs2305480, rs11078927, rs7216389, rs907092, rs4795397, rs11655198, rs62067034, rs2290400, rs4794820, rs12450323 |
rs11557466 | ORMDL3 | Lymphoblastoid | HOXA5, REST, NRSE, HIF1 | rs2305480, rs62067034, rs11078927, rs907092, rs4795397, rs11655198, rs2290400, rs7216389, rs4794820, rs12450323 |
rs8069732 | TBKBP1 | Monocytes | NF-E2, Fos, GCN4, hoxa9, Cdx-2, Hoxa11, Hoxc10, Hoxc11, Hoxc9, Hoxa9, Hoxb9 | rs5918 |