Table 1 Deleterious coding variants in LD with asthma-associated SNPs

rs8084

HLA-DRA

splice acceptor

rs3129890

HLA-DRA

downstream

0.889

< 0.6

0.815

< 0.6

< 0.6

rs199503730

MICA

frameshift

rs361525

TNF, LTA

upstream

< 0.6

< 0.6

< 0.6

< 0.6

0.726

rs67841474

MICA

frameshift

rs2428494

HLA-B

upstream

< 0.6

< 0.6

0.671

< 0.6

< 0.6

rs15895

OAS2

stop lost

rs1293767

OAS2

missense

0.749

0.609

< 0.6

< 0.6

< 0.6

rs11078928

GSDMB

splice acceptor

rs907092

IKZF3

synonymous

< 0.6

0.889

0.845

0.892

0.966

rs4795397

IKZF3

upstream

< 0.6

0.913

0.995

0.950

0.846

rs11655198

ZPBP2

intron

< 0.6

0.804

0.995

0.832

0.898

rs2305480

GSDMB

missense

0.961

0.988

1

0.996

1

rs62067034

GSDMB

intron

0.707

0.871

1

0.849

0.917

rs11078927

GSDMB

intron

0.984

0.994

1

1

0.995

rs2290400

GSDMB

upstream

< 0.6

0.726

0.945

0.811

0.704

rs7216389

GSDMB

upstream

< 0.6

0.831

0.967

0.792

0.723

rs4794820

ORMDL3, LRRC3C

downstream

< 0.6

0.688

0.899

0.731

0.678

rs12450323

IKZF3

intron

< 0.6

< 0.6

0.684

< 0.6

< 0.6

rs146576636

ADAM33

frameshift

rs543749

ADAM33

intron

< 0.6

< 0.6

0.804

< 0.6

< 0.6

rs574174

ADAM33

intron

< 0.6

< 0.6

0.846

< 0.6

< 0.6

rs612709

ADAM33

upstream

< 0.6

< 0.6

0.800

< 0.6

< 0.6