Fig. 2
From: Identification of deleterious and regulatory genomic variations in known asthma loci
Workflow for discovery of potentially causal variants in known asthma loci. First, we compiled and annotated asthma-associated SNPs from previous GWAS and candidate gene studies of asthma. We then determined the genomic coordinates of the 305 genes and extracted all sequence variations within these loci using data from the 1000 Genomes Project (1000GP). Finally, we identified and annotated those variants in linkage disequilibrium (LD) with known asthma loci to determine which may contribute to changes in protein sequence or regulate gene expression (i.e. expression quantitative trait loci or eQTL)