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Table 3 Association of admission sex and mineralocorticoid hormone metabolite levels with short- and long-term all-cause mortality in females with CAP

From: Dihydrotestosterone is a predictor for mortality in males with community-acquired pneumonia: results of a 6-year follow-up study

Females (N = 113) All-cause mortality timepoint
30 days 3 years 6 years
HR (95%CI) p value HR (95%CI) p value HR (95%CI) p value
Progesterone
 Cox regression analyses 0.34 (95%CI 0.004–25.46) p = 0.621 0.24 (95%CI 0.08–0.71) p = 0.010 0.44 (95%CI 0.17–1.14) p = 0.093
17-OH-Progesterone
 Cox regression analyses 0.55 (95%CI 0.09–3.46) p = 0.528 0.99 (95%CI 0.45–2.19) p = 0.979 0.98 (95%CI 0.50–1.93) p = 0.963
Aldosterone
 Cox regression analyses 0.29 (95%CI 0.04–2.14) p = 0.226 0.64 (95%CI 0.30–1.39) p = 0.263 0.81 (95%CI 0.43–1.53) p = 0.516
DHEA
 Cox regression analyses    1.98 (95%CI 0.33–11.97) p = 0.456 1.44 (95%CI 0.30–6.91) p = 0.645
DHEA-S
 Cox regression analyses    0.69 (95%CI 0.22–2.19) p = 0.529 0.55 (95%CI 0.23–1.31) p = 0.178
Androstenedione
 Cox regression analyses 1.41 (95%CI 0.31–6.38) p = 0.652 1.03 (95%CI 0.58–1.83) p = 0.925 1.10 (95%CI 0.68–1.79) p = 0.695
Testosterone
 Cox regression analyses 0.92 (95%CI 0.29–2.92) p = 0.887 0.81 (95%CI 0.40–1.67) p = 0.574 0.91 (95%CI 0.48–1.70) p = 0.758
Dihydrotestosterone
 Cox regression analyses    1.78 (95%CI 0.60–5.25) p = 0.296 1.20 (95%CI 0.56–2.59) p = 0.638
  1. Data for multivariate Cox regression models are presented as HR (95% CI), p value; p values are considered statistically significant at p < 0.05. Bold values indicate statistical significance. All hormone metabolite levels were log-transformed and thus the HR corresponds to a 10-fold increase in these levels. CI confidence interval, DHEA dehydroepiandrosterone, DHEA-S dehydroepiandrosterone sulfate, HR hazard ratio
  2. The multivariate model is adjusted for age and comorbidities (coronary artery disease, cerebrovascular disease, chronic kidney disease, neoplastic disease)