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Table 2 Associations of Chronic Obstructive Pulmonary Disease with Coronary Artery Calciuma

From: Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort

 

Univariate

Multivariableb

β estimate ±SE

p value

β estimate ±SE

p value

FEV1/FVC

−0.723 ± 0.006

< 0.001

−0.192 ± 0.093

0.039

Log Emphysemac

0.348 ± 0.064

< 0.001

−0.075 ± 0.076

0.326

Pi10

0.841 ± 0.207

< 0.001

0.049 ± 0.214

0.819

Centrilobular Emphysema

0.245 ± 0.034

< 0.001

0.073 ± 0.036

0.042

Paraseptal Emphysema

0.102 ± 0.052

0.050

0.031 ± 0.039

0.429

Airway Wall Thickening

0.195 ± 0.046

< 0.001

0.059 ± 0.037

0.112

  1. FEV1 Forced expiratory volume in the first second, FVC Forced vital capacity. Pi10 Square root of the wall area of a theoretical circular cross section of an airway with 10 mm lumenal perimeter
  2. aCoronary artery calcification log transformed. Separate models run for association between CAC and each subtype of chronic obstructive pulmonary disease
  3. bModel adjusted for age, sex, race, BMI, smoking status, pack-years, FEV1, hypertension, diabetes mellitus, statin use, and CT scanner type, except model for FEV1/FVC where FEV1 was not included
  4. cAssessed by percentage of low attenuation areas <-950HU on quantitative CT using density mask analysis
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Respiratory Research

ISSN: 1465-993X

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