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Table 2 Associations of Chronic Obstructive Pulmonary Disease with Coronary Artery Calciuma

From: Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort

  Univariate Multivariableb
β estimate ±SE p value β estimate ±SE p value
FEV1/FVC −0.723 ± 0.006 < 0.001 −0.192 ± 0.093 0.039
Log Emphysemac 0.348 ± 0.064 < 0.001 −0.075 ± 0.076 0.326
Pi10 0.841 ± 0.207 < 0.001 0.049 ± 0.214 0.819
Centrilobular Emphysema 0.245 ± 0.034 < 0.001 0.073 ± 0.036 0.042
Paraseptal Emphysema 0.102 ± 0.052 0.050 0.031 ± 0.039 0.429
Airway Wall Thickening 0.195 ± 0.046 < 0.001 0.059 ± 0.037 0.112
  1. FEV1 Forced expiratory volume in the first second, FVC Forced vital capacity. Pi10 Square root of the wall area of a theoretical circular cross section of an airway with 10 mm lumenal perimeter
  2. aCoronary artery calcification log transformed. Separate models run for association between CAC and each subtype of chronic obstructive pulmonary disease
  3. bModel adjusted for age, sex, race, BMI, smoking status, pack-years, FEV1, hypertension, diabetes mellitus, statin use, and CT scanner type, except model for FEV1/FVC where FEV1 was not included
  4. cAssessed by percentage of low attenuation areas <-950HU on quantitative CT using density mask analysis