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Table 1 Comparison of Demographics and Computed Tomography Characteristics of Participants

From: Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort

  Stratum 1 (n = 75) Stratum 2 (n = 75) Stratum 3 (n = 75) Stratum 4 (n = 75)
Age (years) 54.3 (9.5) 59.8 (9.3) 64.8 (8.5) 64.8 (6.7)
Sex, Male (%) 32 (42.7%) 56 (74.7%) 64 (85.3%) 57 (76.0%)
Race, White (%) 49 (65.3%) 50 (66.7%) 66 (88.0%) 63 (84.0%)
BMI (kg/m2) 28.4 (5.5) 28.3 (4.6) 27.8 (4.0) 26.6 (4.8)
Smoking Pack-years 0 (0) 40.6 (17.5) 49.8 (22.4) 56.5 (21.9)
Hypertension (%) 24 (32%) 31 (41.3%) 42 (56%) 40 (53.3%)
Diabetes mellitus (%) 4 (5.3%) 10 (13.3%) 19 (25.3%) 10 (13.3%)
FEV1 (L) 3.06 (0.69) 3.24 (0.71) 2.79 (0.62) 1.23 (0.26)
FEV1% pred 102.2 (12.1) 101.1 (11.2) 87.0 (15.8) 39.8 (8.1)
FVC (L) 3.76 (0.90) 4.18 (0.92) 4.46 (0.90) 3.20 (0.76)
FVC %pred 97.8 (11.1) 99.9 (11.1) 104.9 (15.6) 77.5 (14.4)
FEV1/FVC 0.82 (0.05) 0.78 (0.05) 0.62 (0.06) 0.39 (0.09)
Percentage Emphysema 1.6 (1.7) 2.0 (1.8) 5.2 (5.1) 17.6 (11.4)
Pi10 3.67 (0.09) 3.68 (0.07) 3.70 (0.08) 3.74 (0.08)
CAC 2.0 (2.8) 3.6 (3.5) 6.5 (4.2) 6.5 (4.0)
Statinsa (%) 19 (25.3%) 25 (33.3%) 45 (60.0%) 32 (42.7%)
Centrilobular Emphysema (%)
 Mild (yes/no) (%) 3 (4%) 13 (17.3%) 20 (26.7%) 8 (10.7%)
 Moderate (yes/no) (%) 0 (0%) 4 (5.3%) 21 (28%) 22 (29.3%)
 Advanced/Confluent (yes/no) (%) 0 (0%) 4 (5.3%) 17 (22.7%) 42 (56%)
 Substantial Paraseptal Emphysema (yes/no) (%) 0 (0%) 10 (13.3.%) 16 (21.3%) 13 (17.3%)
 Definite Bronchial Wall Thickening (yes/no) (%) 0 (0%) 5 (6.7%) 17 (22.7%) 29 (38.7%)
  1. All values shown as mean (standard deviation) unless otherwise stated
  2. FEV1 Forced expiratory volume in the first second, FVC Forced vital capacity, CAC Coronary artery calcification, Pi10 Square root of the wall area of a theoretical circular cross section of an airway with 10 mm lumenal perimeter
  3. Stratum 1 = Lifetime non-smokers
  4. Stratum 2 = Smokers without airflow obstruction. FEV1/FVC ≥0.70
  5. Stratum 3 = Mild to moderate airflow obstruction. FEV1/FVC < 0.70, FEV1 ≥ 50%predicted
  6. Stratum 4 = Severe to very severe airflow obstruction. FEV1/FVC < 0.70, FEV1 < 50%predicted
  7. aMedication data displayed for usage in the three months prior to enrollment