| |
Stratum 1 (n = 75)
|
Stratum 2 (n = 75)
|
Stratum 3 (n = 75)
|
Stratum 4 (n = 75)
|
|---|
|
Age (years)
|
54.3 (9.5)
|
59.8 (9.3)
|
64.8 (8.5)
|
64.8 (6.7)
|
|
Sex, Male (%)
|
32 (42.7%)
|
56 (74.7%)
|
64 (85.3%)
|
57 (76.0%)
|
|
Race, White (%)
|
49 (65.3%)
|
50 (66.7%)
|
66 (88.0%)
|
63 (84.0%)
|
|
BMI (kg/m2)
|
28.4 (5.5)
|
28.3 (4.6)
|
27.8 (4.0)
|
26.6 (4.8)
|
|
Smoking Pack-years
|
0 (0)
|
40.6 (17.5)
|
49.8 (22.4)
|
56.5 (21.9)
|
|
Hypertension (%)
|
24 (32%)
|
31 (41.3%)
|
42 (56%)
|
40 (53.3%)
|
|
Diabetes mellitus (%)
|
4 (5.3%)
|
10 (13.3%)
|
19 (25.3%)
|
10 (13.3%)
|
|
FEV1 (L)
|
3.06 (0.69)
|
3.24 (0.71)
|
2.79 (0.62)
|
1.23 (0.26)
|
|
FEV1% pred
|
102.2 (12.1)
|
101.1 (11.2)
|
87.0 (15.8)
|
39.8 (8.1)
|
|
FVC (L)
|
3.76 (0.90)
|
4.18 (0.92)
|
4.46 (0.90)
|
3.20 (0.76)
|
|
FVC %pred
|
97.8 (11.1)
|
99.9 (11.1)
|
104.9 (15.6)
|
77.5 (14.4)
|
|
FEV1/FVC
|
0.82 (0.05)
|
0.78 (0.05)
|
0.62 (0.06)
|
0.39 (0.09)
|
|
Percentage Emphysema
|
1.6 (1.7)
|
2.0 (1.8)
|
5.2 (5.1)
|
17.6 (11.4)
|
|
Pi10
|
3.67 (0.09)
|
3.68 (0.07)
|
3.70 (0.08)
|
3.74 (0.08)
|
|
CAC
|
2.0 (2.8)
|
3.6 (3.5)
|
6.5 (4.2)
|
6.5 (4.0)
|
|
Statinsa (%)
|
19 (25.3%)
|
25 (33.3%)
|
45 (60.0%)
|
32 (42.7%)
|
|
Centrilobular Emphysema (%)
|
|
Mild (yes/no) (%)
|
3 (4%)
|
13 (17.3%)
|
20 (26.7%)
|
8 (10.7%)
|
|
Moderate (yes/no) (%)
|
0 (0%)
|
4 (5.3%)
|
21 (28%)
|
22 (29.3%)
|
|
Advanced/Confluent (yes/no) (%)
|
0 (0%)
|
4 (5.3%)
|
17 (22.7%)
|
42 (56%)
|
|
Substantial Paraseptal Emphysema (yes/no) (%)
|
0 (0%)
|
10 (13.3.%)
|
16 (21.3%)
|
13 (17.3%)
|
|
Definite Bronchial Wall Thickening (yes/no) (%)
|
0 (0%)
|
5 (6.7%)
|
17 (22.7%)
|
29 (38.7%)
|
- All values shown as mean (standard deviation) unless otherwise stated
- FEV1 Forced expiratory volume in the first second, FVC Forced vital capacity, CAC Coronary artery calcification, Pi10 Square root of the wall area of a theoretical circular cross section of an airway with 10 mm lumenal perimeter
- Stratum 1 = Lifetime non-smokers
- Stratum 2 = Smokers without airflow obstruction. FEV1/FVC ≥0.70
- Stratum 3 = Mild to moderate airflow obstruction. FEV1/FVC < 0.70, FEV1 ≥ 50%predicted
- Stratum 4 = Severe to very severe airflow obstruction. FEV1/FVC < 0.70, FEV1 < 50%predicted
- aMedication data displayed for usage in the three months prior to enrollment
